AIM: Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. MATERIAL AND METHODS: The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. RESULTS: The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. CONCLUSIONS: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone.
AIM: Several injectable materials have been used as osteogenic bone substitutes. However, none has gained universal acceptance. This study was performed to investigate whether or not chitosan-alginate gel/mesenchymal stem cells/bone morphogenetic protein-2 composites are potentially injectable materials for new bone formation. MATERIAL AND METHODS: The composites were injected into the subcutaneous space on the dorsum of nude mice to investigate new bone tissue formation. The composites were examined histologically over a 12-week period. RESULTS: The composites injected into the mouse were able to stimulate new bone formation, which was trabecular in type. CONCLUSIONS: This study showed that chitosan-alginate gel/MSCs/BMP-2 composites could become clinically useful injectable materials to generate new bone.
Authors: Scott J Stephan; Sunil S Tholpady; Brian Gross; Caren E Petrie-Aronin; Edward A Botchway; Lakshmi S Nair; Roy C Ogle; Stephen S Park Journal: Laryngoscope Date: 2010-05 Impact factor: 3.325
Authors: Lisa Haines-Butterick; Karthikan Rajagopal; Monica Branco; Daphne Salick; Ronak Rughani; Matthew Pilarz; Matthew S Lamm; Darrin J Pochan; Joel P Schneider Journal: Proc Natl Acad Sci U S A Date: 2007-04-30 Impact factor: 11.205
Authors: J F Mano; G A Silva; H S Azevedo; P B Malafaya; R A Sousa; S S Silva; L F Boesel; J M Oliveira; T C Santos; A P Marques; N M Neves; R L Reis Journal: J R Soc Interface Date: 2007-12-22 Impact factor: 4.118
Authors: Xiaoning He; Rosemary Dziak; Keya Mao; Robert Genco; Mark Swihart; Mark Swithart; Chunyi Li; Shuying Yang Journal: Tissue Eng Part A Date: 2012-11-16 Impact factor: 3.845