| Literature DB >> 15693717 |
A Ferraz1, D H Faria, M N Benneti, A Brondani da Rocha, G Schwartsmann, A Henriques, G L von Poser.
Abstract
The crude methanolic extracts of six species of Hypericum growing in southern Brazil (Hypericum caprifoliatum Cham. & Schlecht., H. carinatum Griseb., H. connatum Lam., H. myrianthum Cham. & Schlecht., H. polyanthemum Klotzsch ex Reichardt and H. ternum A. St. Hil.) were screened for their antiproliferative activity against two cell lines (HT-29 human colon carcinoma cells and H-460 non-small cell lung carcinoma). The most active crude extracts were those from H. caprifoliatum, H. myrianthum and, to a lesser extent, from H. connatum. All plants were submitted to fractionation with solvents in increasing polarity and re-assayed for the two cell lines used previously, as well as U-373 human malignant glioma cells. The most active fractions were the hexane fractions obtained from H. caprifoliatum, H. myrianthum and H. ternum.Entities:
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Year: 2005 PMID： 15693717 DOI： 10.1016/j.phymed.2003.07.015
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340