| Literature DB >> 15693713 |
I Jantan1, I A A Rafi, J Jalil.
Abstract
Forty-nine methanol extracts of 37 species of Malaysian medicinal plants were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets, using 3H-PAF as a ligand. Among them, the extracts of six Zingiberaceae species (Alpinia galanga Swartz., Boesenbergia pandurata Roxb., Curcuma ochorrhiza Val., C. aeruginosa Roxb., Zingiber officinale Rosc. and Z. zerumbet Koenig.), two Cinnamomum species (C. altissimum Kosterm. and C. pubescens Kochummen.), Goniothalamus malayanus Hook. f. Momordica charantia Linn. and Piper aduncum L. are potential sources of new PAF antagonists, as they showed significant inhibitory effects with IC50 values ranging from 1.2 to 18.4 microg ml(-1).Entities:
Mesh：
Substances：
Year: 2005 PMID： 15693713 DOI： 10.1016/j.phymed.2003.06.006
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340