Non-PET functional imaging techniques: optical.

The strong and steady development of diffuse optical spectroscopy and tomography as new biomedical optics technologies promises to bring these optical techniques into clinical practice. This article provides a brief review of the light-tissue interaction, the instrumentation, and the theory relevant to this field. This is followed by a survey of the three main applications: brain imaging, muscle imaging, and breast imaging. Lastly, the future outlook of the technology is presented, highlighting the new promises based on recent breakthroughs.