Parvovirus B19: another agent associated with remitting seronegative symmetrical synovitis with pitting edema.

A number of conditions have been associated with remitting seronegative symmetrical synovitis with pitting edema (RS3PE) and the controversy of whether this should be considered a syndrome rather than a disease continues. There are few reports on the role of infectious agents in the etiology of RS3PE, and human parvovirus B19 has not previously been linked to this syndrome. We describe a patient with RS3PE syndrome in association with positive serology and viremia for parvovirus B19. A 9-year followup failed to uncover another cause for RS3PE.