OBJECTIVE: The association between serum antibody levels to major periodontal pathogens and coronary heart disease (CHD) was analyzed in a prospective population-based study. METHODS AND RESULTS: The population comprised 1023 men (aged 46 to 64 years) in the Kuopio Ischemic Heart Disease Study. The subjects with CHD at baseline (n=113) were more often seropositive for Porphyromonas gingivalis IgA (38.9% versus 28.5%, P=0.021) and IgG (60.2% versus 46.7%, P=0.007) than those without CHD. During the 10-year follow-up, 109 men free from CHD at baseline experienced an acute myocardial infarction or CHD death. The men with an end point were more often seropositive for Actinobacillus actinomycetemcomitans IgA (15.5% versus 10.2%, P=0.019) than those who remained healthy. In the highest tertile of A. actinomycetemcomitans IgA-antibodies compared with the lowest one, the relative risk (RR) for an end point adjusted for CHD risk factors was 2.0 (95% confidence interval [CI], 1.2 to 3.3). In the Porphyromonas gingivalis IgA-antibody tertiles, the highest RR of 2.1 (1.3 to 3.4) was observed in the second tertile. All antibody levels correlated positively with the carotid artery intima-media thickness. CONCLUSIONS: High-serum antibody levels to major periodontal pathogens are associated with subclinical, prevalent, and future incidence of CHD. Periodontal pathogens or host response against them may contribute to the pathogenesis of CHD.
OBJECTIVE: The association between serum antibody levels to major periodontal pathogens and coronary heart disease (CHD) was analyzed in a prospective population-based study. METHODS AND RESULTS: The population comprised 1023 men (aged 46 to 64 years) in the Kuopio Ischemic Heart Disease Study. The subjects with CHD at baseline (n=113) were more often seropositive for Porphyromonas gingivalis IgA (38.9% versus 28.5%, P=0.021) and IgG (60.2% versus 46.7%, P=0.007) than those without CHD. During the 10-year follow-up, 109 men free from CHD at baseline experienced an acute myocardial infarction or CHD death. The men with an end point were more often seropositive for Actinobacillus actinomycetemcomitans IgA (15.5% versus 10.2%, P=0.019) than those who remained healthy. In the highest tertile of A. actinomycetemcomitans IgA-antibodies compared with the lowest one, the relative risk (RR) for an end point adjusted for CHD risk factors was 2.0 (95% confidence interval [CI], 1.2 to 3.3). In the Porphyromonas gingivalis IgA-antibody tertiles, the highest RR of 2.1 (1.3 to 3.4) was observed in the second tertile. All antibody levels correlated positively with the carotid artery intima-media thickness. CONCLUSIONS: High-serum antibody levels to major periodontal pathogens are associated with subclinical, prevalent, and future incidence of CHD. Periodontal pathogens or host response against them may contribute to the pathogenesis of CHD.
Authors: S Janket; J H Meurman; A E Baird; M Qvarnström; P Nuutinen; L K Ackerson; J Hong; P Muthukrishnan; T E Van Dyke Journal: J Dent Res Date: 2010-02-22 Impact factor: 6.116
Authors: Kati Hyvärinen; Anita M Tuomainen; Saara Laitinen; Igor L Bykov; Liisa Törmäkangas; Kai Lindros; Reijo Käkelä; Georg Alfthan; Irma Salminen; Matti Jauhiainen; Petri T Kovanen; Maija Leinonen; Pekka Saikku; Pirkko J Pussinen Journal: Infect Immun Date: 2009-05-18 Impact factor: 3.441
Authors: Ryan T Demmer; Thomas Kocher; Christian Schwahn; Henry Völzke; David R Jacobs; Moïse Desvarieux Journal: Community Dent Oral Epidemiol Date: 2008-04-14 Impact factor: 3.383
Authors: K Yamazaki; T Honda; H Domon; T Okui; K Kajita; R Amanuma; C Kudoh; S Takashiba; S Kokeguchi; F Nishimura; M Kodama; Y Aizawa; H Oda Journal: Clin Exp Immunol Date: 2007-07-23 Impact factor: 4.330