| Literature DB >> 15691756 |
Abstract
In a recent issue of Molecular Cell, Papayannopoulos et al. (2005) show that N-WASP activation of actin-related protein2/3 (Arp2/3) is ultrasensitive to PI(4,5)P(2) concentration. We discuss how interactions between basic regions in proteins and negatively charged membranes can produce sharp on-off switches that may regulate biological activity.Entities:
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Year: 2005 PMID： 15691756 DOI： 10.1016/j.devcel.2005.01.002
Source DB: PubMed Journal: Dev Cell ISSN： 1534-5807 Impact factor: 12.270