Literature DB >> 15691064

Immunoprotective potential of polysaccharide-tetanus toxoid conjugate in Klebsiella pneumoniae induced lobar pneumonia in rats.

S Chhibber1, Mamta Rani, Yadav Vanashree.   

Abstract

The polysaccharide (PS) derived from K. pneumoniae NCTC 5055 lipopolysaccharide (LPS) was covalently linked to tetanus toxoid by using carbodimide with adipic acid dihydrazide as a spacer molecule. The conjugate was found to be non-toxic and non-pyrogenic at 100 microg dose level. At a similar dose, the conjugate did not elicit any local skin reaction on intradermal preparatory injection in rabbits. The conjugate was immunoprotective as was evident from the decrease in relative colonization of bacteria in lungs of immunized rats as compared to the control animals. Immunization with the conjugate resulted in alveolar macrophage activation in terms of their ability to phagocytose bacteria in vitro.

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Year:  2005        PMID： 15691064

Source DB:  PubMed          Journal:  Indian J Exp Biol        ISSN： 0019-5189            Impact factor:   0.818


  7 in total

1.  Progress towards the development of Klebsiella vaccines.

Authors:  Myeongjin Choi; Sharon M Tennant; Raphael Simon; Alan S Cross
Journal:  Expert Rev Vaccines       Date:  2019-06-28       Impact factor: 5.217

2.  The Diversity of Lipopolysaccharide (O) and Capsular Polysaccharide (K) Antigens of Invasive Klebsiella pneumoniae in a Multi-Country Collection.

Authors:  Myeongjin Choi; Nicolas Hegerle; Joseph Nkeze; Shaichi Sen; Sanchita Jamindar; Shamima Nasrin; Sunil Sen; Jasnehta Permala-Booth; James Sinclair; Milagritos D Tapia; J Kristie Johnson; Sylla Mamadou; Joshua T Thaden; Vance G Fowler; Ana Aguilar; Enrique Terán; Dominique Decre; Florence Morel; Karen Angeliki Krogfelt; Annelie Brauner; Efthymia Protonotariou; Eirini Christaki; Yuichiro Shindo; Yi-Tsung Lin; Andrea L Kwa; Sadia Shakoor; Ashika Singh-Moodley; Olga Perovic; Jan Jacobs; Octavie Lunguya; Raphael Simon; Alan S Cross; Sharon M Tennant
Journal:  Front Microbiol       Date:  2020-06-12       Impact factor: 5.640

3.  Production of a Promising Biosynthetic Self-Assembled Nanoconjugate Vaccine against Klebsiella Pneumoniae Serotype O2 in a General Escherichia Coli Host.

Authors:  Zhehui Peng; Jun Wu; Kangfeng Wang; Xin Li; Peng Sun; Lulu Zhang; Jing Huang; Yan Liu; Xiaoting Hua; Yunsong Yu; Chao Pan; Hengliang Wang; Li Zhu
Journal:  Adv Sci (Weinh)       Date:  2021-05-24       Impact factor: 16.806

Review 4.  Development of a new trend conjugate vaccine for the prevention of Klebsiella pneumoniae.

Authors:  Tarek A Ahmad; Medhat Haroun; Ahmad A Hussein; El Sayed H El Ashry; Laila H El-Sayed
Journal:  Infect Dis Rep       Date:  2012-07-23

5.  Fighting Antibiotic-Resistant Klebsiella pneumoniae with "Sweet" Immune Targets.

Authors:  Roberto Adamo; Immaculada Margarit
Journal:  mBio       Date:  2018-05-15       Impact factor: 7.867

Review 6.  Potential targets for next generation antimicrobial glycoconjugate vaccines.

Authors:  Francesca Micoli; Paolo Costantino; Roberto Adamo
Journal:  FEMS Microbiol Rev       Date:  2018-05-01       Impact factor: 16.408

7.  Development of a broad spectrum glycoconjugate vaccine to prevent wound and disseminated infections with Klebsiella pneumoniae and Pseudomonas aeruginosa.

Authors:  Nicolas Hegerle; Myeongjin Choi; James Sinclair; Mohammed N Amin; Morgane Ollivault-Shiflett; Brittany Curtis; Rachel S Laufer; Surekha Shridhar; Jerod Brammer; Franklin R Toapanta; Ian Alan Holder; Marcela F Pasetti; Andrew Lees; Sharon M Tennant; Alan S Cross; Raphael Simon
Journal:  PLoS One       Date:  2018-09-06       Impact factor: 3.240
  7 in total

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