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Literature DB >> 15690078

Rab27a: a new face in beta cell metabolism-secretion coupling.

Abstract

In pancreatic beta cells, not only insulin exocytosis per se, but translocation of beta granules toward the plasma membrane--an event upstream of exocytosis--are under the control of glucose. However, the molecular basis of this translocation has been poorly understood. Rab27a-mediated translocation of glucose-induced beta granules is reported in this issue of the JCI. Rab27a or its effector molecule may constitute a novel pharmacological target because potentiation of the Rab27a pathway is expected to restore beta cell glucose competency in patients with diabetes mellitus.

Entities: Chemical Disease Gene Species

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Year: 2005 PMID： 15690078 PMCID： PMC546431 DOI： 10.1172/JCI24269

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

24 in total

1. Rab27a mediates the tight docking of insulin granules onto the plasma membrane during glucose stimulation.

Authors: Kazuo Kasai; Mica Ohara-Imaizumi; Noriko Takahashi; Shin Mizutani; Shengli Zhao; Toshiteru Kikuta; Haruo Kasai; Shinya Nagamatsu; Hiroshi Gomi; Tetsuro Izumi
Journal: J Clin Invest Date: 2005-02 Impact factor: 14.808

Review 2. Importance of nonionic signals for glucose-induced biphasic insulin secretion.

Authors: Toru Aizawa; Yoshihiko Sato; Mitsuhisa Komatsu
Journal: Diabetes Date: 2002-02 Impact factor: 9.461

3. Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.

Authors: S Farfari; V Schulz; B Corkey; M Prentki
Journal: Diabetes Date: 2000-05 Impact factor: 9.461

4. Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets.

Authors: Linda I Nicholls; Edward K Ainscow; Guy A Rutter
Journal: Biochem Biophys Res Commun Date: 2002-03-08 Impact factor: 3.575

Review 5. The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction.

Authors: B E Corkey; J T Deeney; G C Yaney; K Tornheim; M Prentki
Journal: J Nutr Date: 2000-02 Impact factor: 4.798

Review 6. Triggering and amplifying pathways of regulation of insulin secretion by glucose.

Authors: J C Henquin
Journal: Diabetes Date: 2000-11 Impact factor: 9.461

7. Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis.

Authors: P Maechler; C B Wollheim
Journal: Nature Date: 1999-12-09 Impact factor: 49.962

8. Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex.

Authors: Debbie C Thurmond; Carmen Gonelle-Gispert; Megumi Furukawa; Philippe A Halban; Jeffrey E Pessin
Journal: Mol Endocrinol Date: 2003-01-16

9. Insulin secretory deficiency and glucose intolerance in Rab3A null mice.

Authors: Kazuro Yaekura; Richard Julyan; Barton L Wicksteed; Lori B Hays; Cristina Alarcon; Scott Sommers; Vincent Poitout; Denis G Baskin; Yong Wang; Louis H Philipson; Christopher J Rhodes
Journal: J Biol Chem Date: 2003-01-01 Impact factor: 5.157

10. Physiological and pathophysiological roles of ATP-sensitive K+ channels.

Authors: Susumu Seino; Takashi Miki
Journal: Prog Biophys Mol Biol Date: 2003-02 Impact factor: 3.667

15 in total

1. Enhancement of the incretin pathway in response to bariatric surgery is important for restoration of beta cell function.

Authors: M Komatsu; T Aizawa
Journal: Diabetologia Date: 2008-11-27 Impact factor: 10.122

2. The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.

Authors: Chong Wee Liew; Jacek Bochenski; Dan Kawamori; Jiang Hu; Colin A Leech; Krzysztof Wanic; Maciej Malecki; James H Warram; Ling Qi; Andrzej S Krolewski; Rohit N Kulkarni
Journal: J Clin Invest Date: 2010-07-01 Impact factor: 14.808

3. PI3K p110α/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport.

Authors: Jing Li; Jun Song; Margaret G Cassidy; Piotr Rychahou; Marlene E Starr; Jianyu Liu; Xin Li; Garretson Epperly; Heidi L Weiss; Courtney M Townsend; Tianyan Gao; B Mark Evers
Journal: Mol Endocrinol Date: 2012-06-14

4. Glucotoxicity promotes aberrant activation and mislocalization of Ras-related C3 botulinum toxin substrate 1 [Rac1] and metabolic dysfunction in pancreatic islet β-cells: reversal of such metabolic defects by metformin.

Authors: Sartaj Baidwan; Anil Chekuri; DiAnna L Hynds; Anjaneyulu Kowluru
Journal: Apoptosis Date: 2017-11 Impact factor: 4.677

5. In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets.

Authors: Karen Piper Hanley; Tom Hearn; Andrew Berry; Melanie J Carvell; Ann-Marie Patch; Louise J Williams; Sarah A Sugden; David I Wilson; Sian Ellard; Neil A Hanley
Journal: J Endocrinol Date: 2010-08-31 Impact factor: 4.286

Review 6. Emerging roles for protein histidine phosphorylation in cellular signal transduction: lessons from the islet beta-cell.

Authors: Anjaneyulu Kowluru
Journal: J Cell Mol Med Date: 2008-04-08 Impact factor: 5.310