Literature DB >> 15688065

ADAMs: key components in EGFR signalling and development.

Carl P Blobel1.   

Abstract

ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored metalloproteases that process and shed the ectodomains of membrane-anchored growth factors, cytokines and receptors. ADAMs also have essential roles in fertilization, angiogenesis, neurogenesis, heart development and cancer. Research on ADAMs and their role in protein ectodomain shedding is emerging as a fertile ground for gathering new insights into the functional regulation of membrane proteins.

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Year:  2005        PMID： 15688065     DOI： 10.1038/nrm1548

Source DB:  PubMed          Journal:  Nat Rev Mol Cell Biol        ISSN： 1471-0072            Impact factor:   94.444


  426 in total

1.  Expression patterns of ADAMs in the developing chicken lens.

Authors:  Xin Yan; Juntang Lin; Arndt Rolfs; Jiankai Luo
Journal:  J Mol Histol       Date:  2012-01-14       Impact factor: 2.611

2.  VIP36 protein is a target of ectodomain shedding and regulates phagocytosis in macrophage Raw 264.7 cells.

Authors:  Kyoko Shirakabe; Seisuke Hattori; Motoharu Seiki; Shigeo Koyasu; Yasunori Okada
Journal:  J Biol Chem       Date:  2011-10-20       Impact factor: 5.157

3.  ADAM15 protein amplifies focal adhesion kinase phosphorylation under genotoxic stress conditions.

Authors:  Dorothee Fried; Beate B Böhm; Kristin Krause; Harald Burkhardt
Journal:  J Biol Chem       Date:  2012-04-27       Impact factor: 5.157

4.  Fell-Muir Lecture: Metalloproteinases: from demolition squad to master regulators.

Authors:  Gillian Murphy
Journal:  Int J Exp Pathol       Date:  2010-08       Impact factor: 1.925

Review 5.  The regulatory crosstalk between kinases and proteases in cancer.

Authors:  Carlos López-Otín; Tony Hunter
Journal:  Nat Rev Cancer       Date:  2010-03-19       Impact factor: 60.716

6.  Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes.

Authors:  Gisela Weskamp; Karen Mendelson; Steve Swendeman; Sylvain Le Gall; Yan Ma; Stephen Lyman; Akinari Hinoki; Satoru Eguchi; Victor Guaiquil; Keisuke Horiuchi; Carl P Blobel
Journal:  Circ Res       Date:  2010-01-28       Impact factor: 17.367

7.  Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D.

Authors:  Casey M Kraning-Rush; Shawn P Carey; Marsha C Lampi; Cynthia A Reinhart-King
Journal:  Integr Biol (Camb)       Date:  2013-03       Impact factor: 2.192

8.  Anti-inflammatory macrophages activate invasion in pancreatic adenocarcinoma by increasing the MMP9 and ADAM8 expression.

Authors:  Pauli Puolakkainen; Aino Koski; Sanna Vainionpää; Zhanlong Shen; Heikki Repo; Esko Kemppainen; Harri Mustonen; Hanna Seppänen
Journal:  Med Oncol       Date:  2014-02-14       Impact factor: 3.064

9.  Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.

Authors:  Nagaraj S Nagathihalli; Yugandhar Beesetty; Wooin Lee; M Kay Washington; Xi Chen; A Craig Lockhart; Nipun B Merchant
Journal:  Cancer Res       Date:  2014-02-11       Impact factor: 12.701

Review 10.  The pleiotropic roles of ADAM9 in the biology of solid tumors.

Authors:  Victor O Oria; Paul Lopatta; Oliver Schilling
Journal:  Cell Mol Life Sci       Date:  2018-03-17       Impact factor: 9.261
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