Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator CsrA.

Literature DB >> 15687220

The Hfq homolog in Legionella pneumophila demonstrates regulation by LetA and RpoS and interacts with the global regulator CsrA.

Tamara L McNealy¹, Vera Forsbach-Birk, Chunwei Shi, Reinhard Marre.

Abstract

A gene in Legionella pneumophila that has significant homology to published hfq genes demonstrated regulation by RpoS and the transcriptional regulator LetA. Additionally, Hfq has a positive effect on the presence of transcripts of the genes for CsrA and the ferric uptake regulator Fur. Mutants lacking hfq demonstrate defects in growth and pigmentation and slight defects in virulence in both amoeba and macrophage infection models. Hfq appears to play a major role in exponential-phase regulatory cascades of L. pneumophila.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2005 PMID： 15687220 PMCID： PMC545622 DOI： 10.1128/JB.187.4.1527-1532.2005

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

38 in total

1. Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome binding.

Authors: O Vytvytska; I Moll; V R Kaberdin; A von Gabain; U Bläsi
Journal: Genes Dev Date: 2000-05-01 Impact factor: 11.361

2. Host factor Hfq of Escherichia coli stimulates elongation of poly(A) tails by poly(A) polymerase I.

Authors: E Hajnsdorf; P Régnier
Journal: Proc Natl Acad Sci U S A Date: 2000-02-15 Impact factor: 11.205

3. A two-component regulator induces the transmission phenotype of stationary-phase Legionella pneumophila.

Authors: Brian K Hammer; Eiko S Tateda; Michele S Swanson
Journal: Mol Microbiol Date: 2002-04 Impact factor: 3.501

4. A trans-acting RNA as a control switch in Escherichia coli: DsrA modulates function by forming alternative structures.

Authors: R A Lease; M Belfort
Journal: Proc Natl Acad Sci U S A Date: 2000-08-29 Impact factor: 11.205

5. Alveolar macrophage cell line MH-S is valuable as an in vitro model for Legionella pneumophila infection.

Authors: K Matsunaga; T W Klein; H Friedman; Y Yamamoto
Journal: Am J Respir Cell Mol Biol Date: 2001-03 Impact factor: 6.914

6. Functional replacement of the Escherichia coli hfq gene by the homologue of Pseudomonas aeruginosa.

Authors: Elisabeth Sonnleitner; Isabella Moll; Udo Bläsi
Journal: Microbiology Date: 2002-03 Impact factor: 2.777

7. RpoS co-operates with other factors to induce Legionella pneumophila virulence in the stationary phase.

Authors: M A Bachman; M S Swanson
Journal: Mol Microbiol Date: 2001-06 Impact factor: 3.501

8. Overexpresssion of a Legionella pneumophila homologue of the E. coli regulator csrA affects cell size, flagellation, and pigmentation.

Authors: P S Fettes; V Forsbach-Birk; D Lynch; R Marre
Journal: Int J Med Microbiol Date: 2001-11 Impact factor: 3.473

9. Co-ordination of legionella pneumophila virulence with entry into stationary phase by ppGpp.

Authors: B K Hammer; M S Swanson
Journal: Mol Microbiol Date: 1999-08 Impact factor: 3.501

10. Hfq is essential for Vibrio cholerae virulence and downregulates sigma expression.

Authors: Yanpeng Ding; Brigid M Davis; Matthew K Waldor
Journal: Mol Microbiol Date: 2004-07 Impact factor: 3.501

36 in total

1. Hfq virulence regulation in enterohemorrhagic Escherichia coli O157:H7 strain 86-24.

Authors: Melissa M Kendall; Charley C Gruber; David A Rasko; David T Hughes; Vanessa Sperandio
Journal: J Bacteriol Date: 2011-10-07 Impact factor: 3.490

2. The response regulator CpxR directly regulates expression of several Legionella pneumophila icm/dot components as well as new translocated substrates.

Authors: Efrat Altman; Gil Segal
Journal: J Bacteriol Date: 2008-01-11 Impact factor: 3.490

3. The RNA chaperone Hfq is involved in stress response and virulence in Neisseria meningitidis and is a pleiotropic regulator of protein expression.

Authors: Laura Fantappiè; Matteo M E Metruccio; Kate L Seib; Francesca Oriente; Elena Cartocci; Francesca Ferlicca; Marzia M Giuliani; Vincenzo Scarlato; Isabel Delany
Journal: Infect Immun Date: 2009-02-17 Impact factor: 3.441

4. SigmaS controls multiple pathways associated with intracellular multiplication of Legionella pneumophila.

Authors: Galadriel Hovel-Miner; Sergey Pampou; Sebastien P Faucher; Margaret Clarke; Irina Morozova; Pavel Morozov; James J Russo; Howard A Shuman; Sergey Kalachikov
Journal: J Bacteriol Date: 2009-02-13 Impact factor: 3.490

5. Reciprocal expression of integration host factor and HU in the developmental cycle and infectivity of Legionella pneumophila.

Authors: Michael G Morash; Ann Karen C Brassinga; Michelle Warthan; Poornima Gourabathini; Rafael A Garduño; Steven D Goodman; Paul S Hoffman
Journal: Appl Environ Microbiol Date: 2009-02-05 Impact factor: 4.792

10. The GacS/GacA signal transduction system of Pseudomonas aeruginosa acts exclusively through its control over the transcription of the RsmY and RsmZ regulatory small RNAs.

Authors: Anja Brencic; Kirsty A McFarland; Heather R McManus; Sandra Castang; Ilaria Mogno; Simon L Dove; Stephen Lory
Journal: Mol Microbiol Date: 2009-07-09 Impact factor: 3.501