Literature DB >> 15686944

7alpha,11beta-Dimethyl-19-nortestosterone: a potent and selective androgen response modulator with prostate-sparing properties.

C Edgar Cook1, John A Kepler.   

Abstract

7alpha,11beta-Dimethyl-19-nortestosterone, made by 1,6-methyl addition to 17beta-acetoxy-11beta-methylestra-4,6-dien-3-one, was a highly potent and selective androgen response modulator, with enhanced androgen receptor binding, androgenic activity and anabolic:androgenic ratio over its two monomethyl homologs.

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Year:  2005        PMID： 15686944     DOI： 10.1016/j.bmcl.2004.11.076

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Single, escalating dose pharmacokinetics, safety and food effects of a new oral androgen dimethandrolone undecanoate in man: a prototype oral male hormonal contraceptive.

Authors:  Prasanth Surampudi; Stephanie T Page; Ronald S Swerdloff; Jean Jacques Nya-Ngatchou; Peter Y Liu; John K Amory; Andrew Leung; Laura Hull; Diana L Blithe; Jason Woo; William J Bremner; Christina Wang
Journal:  Andrology       Date:  2014-05-02       Impact factor: 3.842

Review 2.  Does ethnicity matter in male hormonal contraceptive efficacy?

Authors:  Niloufar Ilani; Peter Y Liu; Ronald S Swerdloff; Christina Wang
Journal:  Asian J Androl       Date:  2011-02-14       Impact factor: 3.285

3.  Comparison of the single dose pharmacokinetics, pharmacodynamics, and safety of two novel oral formulations of dimethandrolone undecanoate (DMAU): a potential oral, male contraceptive.

Authors:  R Ayoub; S T Page; R S Swerdloff; P Y Liu; J K Amory; A Leung; L Hull; D Blithe; A Christy; J H Chao; W J Bremner; C Wang
Journal:  Andrology       Date:  2016-12-01       Impact factor: 4.456

4.  Safety and Pharmacokinetics of Single-Dose Novel Oral Androgen 11β-Methyl-19-Nortestosterone-17β-Dodecylcarbonate in Men.

Authors:  Sherry Wu; Fiona Yuen; Ronald S Swerdloff; Youngju Pak; Arthi Thirumalai; Peter Y Liu; John K Amory; Feng Bai; Laura Hull; Diana L Blithe; Bradley D Anawalt; Toufan Parman; Kyuri Kim; Min S Lee; William J Bremner; Stephanie T Page; Christina Wang
Journal:  J Clin Endocrinol Metab       Date:  2019-03-01       Impact factor: 6.134
  4 in total

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