Literature DB >> 15686942

Synthesis and structure-activity relationships of isoxazole carboxamides as growth hormone secretagogue receptor antagonists.

Zhili Xin1, Hongyu Zhao, Michael D Serby, Bo Liu, Verlyn G Schaefer, Douglas H Falls, Wiweka Kaszubska, Christine A Colins, Hing L Sham, Gang Liu.   

Abstract

A series of isoxazole carboxamide derivatives has been developed as potent ghrelin receptor antagonists. The synthesis and structure-activity relationship (SAR) are described.

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Year:  2005        PMID： 15686942     DOI： 10.1016/j.bmcl.2004.11.075

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

Review 1.  Constitutive activation of G protein-coupled receptors and diseases: insights into mechanisms of activation and therapeutics.

Authors:  Ya-Xiong Tao
Journal:  Pharmacol Ther       Date:  2008-08-09       Impact factor: 12.310

2.  Improved synthesis of 3-aryl isoxazoles containing fused aromatic rings.

Authors:  Yousef R Mirzaei; Matthew J Weaver; Scott A Steiger; Alison K Kearns; Mariusz P Gajewski; Kevin C Rider; Howard D Beall; N R Natale
Journal:  Tetrahedron       Date:  2012-09-25       Impact factor: 2.457
  2 in total

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