Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action.

Literature DB >> 15686939

Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action.

Jens Pohlmann¹, Thomas Lampe, Mitsuyuki Shimada, Peter G Nell, Josef Pernerstorfer, Niels Svenstrup, Nina A Brunner, Guido Schiffer, Christoph Freiberg.

Abstract

The pseudopeptide pyrrolidinedione natural products moiramide B and andrimid represent a new class of antibiotics that target bacterial fatty acid biosynthesis. Structure-activity relationship (SAR) studies revealed a high degree of variability for the fatty acid side chain, allowing optimization of physicochemical parameters, and a restricted SAR for the pyrrolidinedione group, indicating major relevance of this subunit for efficient target binding.

Entities: Chemical

Mesh：

Substances：

Year: 2005 PMID： 15686939 DOI： 10.1016/j.bmcl.2004.12.002

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

Keyword Cloud
Cited

19 in total

1. Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes.

Authors: Michael A Fischbach; Jonathan R Lai; Eric D Roche; Christopher T Walsh; David R Liu
Journal: Proc Natl Acad Sci U S A Date: 2007-07-09 Impact factor: 11.205

2. ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria.

Authors: Daniel G Kurth; Gabriela M Gago; Agustina de la Iglesia; Bernardo Bazet Lyonnet; Ting-Wan Lin; Héctor R Morbidoni; Shiou-Chuan Tsai; Hugo Gramajo
Journal: Microbiology (Reading) Date: 2009-05-07 Impact factor: 2.777

3. Novel bacterial acetyl coenzyme A carboxylase inhibitors with antibiotic efficacy in vivo.

Authors: C Freiberg; J Pohlmann; P G Nell; R Endermann; J Schuhmacher; B Newton; M Otteneder; T Lampe; D Häbich; K Ziegelbauer
Journal: Antimicrob Agents Chemother Date: 2006-08 Impact factor: 5.191

Review 4. Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

Authors: Joshua B Parsons; Charles O Rock
Journal: Curr Opin Microbiol Date: 2011-08-20 Impact factor: 7.934

5. Gene expression analysis of wild Leishmania major isolates: identification of genes preferentially expressed in amastigotes.

Authors: Meriem Ouakad; Mehdi Chenik; Yosser Ben Achour-Chenik; Hechmi Louzir; Koussay Dellagi
Journal: Parasitol Res Date: 2006-10-03 Impact factor: 2.289

Pyrrolidinedione derivatives as antibacterial agents with a novel mode of action.

1. Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes.

2. ACCase 6 is the essential acetyl-CoA carboxylase involved in fatty acid and mycolic acid biosynthesis in mycobacteria.

3. Novel bacterial acetyl coenzyme A carboxylase inhibitors with antibiotic efficacy in vivo.

Review 4. Is bacterial fatty acid synthesis a valid target for antibacterial drug discovery?

5. Gene expression analysis of wild Leishmania major isolates: identification of genes preferentially expressed in amastigotes.

6. A biosynthetic gene cluster for the acetyl-CoA carboxylase inhibitor andrimid.

Review 7. Fatty acid biosynthesis in actinomycetes.

Review 8. Bacterial fatty acid metabolism in modern antibiotic discovery.

9. Diversity of antibiotic-active bacteria associated with the brown alga Laminaria saccharina from the Baltic Sea.

10. Andrimid producers encode an acetyl-CoA carboxyltransferase subunit resistant to the action of the antibiotic.