| Literature DB >> 15686937 |
Boris Rocić1, Marijana Vucić-Lovrencić, Nevenka Poje, Mirko Poje, Federico Bertuzzi.
Abstract
Uric acid (1a) suppresses basal insulin release in isolated rat pancreatic islets and inhibition of glucose-stimulated insulin secretion (GSIS) occurs right at hyperuricaemic levels (0.4 mM). Conversely, 1 mM guanidinium urate (2a) was completely ineffective, strongly suggesting that binding to an essential arginine residue triggers the inhibitory effect. A specific recognition of 1a molecule at the crucial beta-cell receptor is probably involved in the blocking glucose signal transduction.Entities:
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Year: 2005 PMID： 15686937 DOI： 10.1016/j.bmcl.2004.12.003
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823