| Literature DB >> 15686935 |
Alexandre Légora Machado1, Lídia Moreira Lima, João Xavier Araújo, Carlos Alberto M Fraga, Vera Lúcia Gonçalves Koatz, Eliezer J Barreiro.
Abstract
As part of an ongoing effort to develop new thalidomide analogues as antiinflammatory lead-candidates, this paper describes the synthesis and antiinflammatory activity of novel N-phenyl-phthalimide functionalized derivatives (4a-d, 5a,b, 6a,b). The target compounds were assayed in an acute lung inflammatory model and all compounds were able to inhibit TNF-alpha production and subsequent neutrophil recruitment in the LPS-acute lung inflammatory model.Entities:
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Year: 2005 PMID： 15686935 DOI： 10.1016/j.bmcl.2004.12.012
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823