| Literature DB >> 15686923 |
Daisuke Kamiya1, Yuki Uchihata, Eiko Ichikawa, Kuniki Kato, Kazuo Umezawa.
Abstract
Suppression of resistance to anticancer drugs by COTC of glyoxalase I (GloI) inhibitor targeting intracellular glutathione (GSH) and GloI was studied. Depletion of the cellular GSH content and inhibition of GloI by COTC increased chemotherapy-mediated apoptosis in apoptosis-resistant pancreatic adenocarcinoma AsPC-1 cells.Entities:
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Year: 2005 PMID： 15686923 DOI： 10.1016/j.bmcl.2004.12.031
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823