| Literature DB >> 15686920 |
Lucjan Strekowski1, Maryam Hojjat, Ewa Wolinska, Alesia N Parker, Ekaterina Paliakov, Tadeusz Gorecki, Farial A Tanious, W David Wilson.
Abstract
Several substituted quinolin-4-amines and heteroaromatic analogs were synthesized and evaluated for interaction with triplex polydA.2polydT and duplex polydA.polydT by using UV-thermal melting experiments. Excellent triple-helix DNA ligands with high affinity toward T.A.T triplets and triple/duplex selectivity were designed through a rational approach.Entities:
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Year: 2005 PMID： 15686920 DOI： 10.1016/j.bmcl.2004.12.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823