| Literature DB >> 15686911 |
Takeshi Ochi1, Masato Sakamoto, Akira Minamida, Kenji Suzuki, Tomohiko Ueda, Teruaki Une, Hiroshi Toda, Kazuya Matsumoto, Yoshiaki Terauchi.
Abstract
Two major metabolites in humans of blonanserin, 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta-[b]pyridine (code name AD-5423), were synthesized. The first, 7-hydroxylated AD-5423, was synthesized through a four-step process starting from 4-fluorobenzoylacetonitrile (1), and the second, 8-hydroxylated AD-5423, a nine-step process also from 1. The optical resolution, structures, and receptor binding properties of the metabolites were documented.Entities:
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Year: 2005 PMID： 15686911 DOI： 10.1016/j.bmcl.2004.12.028
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823