Literature DB >> 15686878

Synthesis and biological activity of the tea catechin metabolites, M4 and M6 and their methoxy-derivatives.

Joshua D Lambert1, Joseph E Rice, Jungil Hong, Zhe Hou, Chung S Yang.   

Abstract

Syntheses are reported for metabolites M4 (1) and M6 (2) of the green tea polyphenols epicatechin (EC) and epigallocatechin (EGC) and their gallate derivatives. Several methoxy-derivatives of 1 and 2 were also prepared. Compounds 1 and 2 were evaluated for growth inhibitory activity against a panel of immortalized and malignant human cell lines with 1 being the more active compound. The possible antiinflammatory activity of 1 and its trimethoxy derivative was also evaluated. Neither compound inhibited the release of arachidonic acid, although 1 inhibited NO production by 50% at 20 microM.

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Year:  2005        PMID： 15686878     DOI： 10.1016/j.bmcl.2004.12.070

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Building addressable libraries: site-selective use of Pd(0) catalysts on microelectrode arrays.

Authors:  Libo Hu; Melissae Stuart; Jun Tian; Karl Maurer; Kevin D Moeller
Journal:  J Am Chem Soc       Date:  2010-11-02       Impact factor: 15.419

2.  A preliminary investigation of the impact of catechol-O-methyltransferase genotype on the absorption and metabolism of green tea catechins.

Authors:  Rosalind J Miller; Kim G Jackson; Tony Dadd; Beate Nicol; Joanne L Dick; Andrew E Mayes; A Louise Brown; Anne M Minihane
Journal:  Eur J Nutr       Date:  2011-03-29       Impact factor: 5.614

3.  Inhibitory Effect of Orientin on Secretory Group IIA Phospholipase A2.

Authors:  Jong-Sup Bae
Journal:  Inflammation       Date:  2015-08       Impact factor: 4.092

4.  Site-selective chemistry and the attachment of peptides to the surface of a microelectrode array.

Authors:  Melissae Stuart Fellet; Jennifer L Bartels; Bo Bi; Kevin D Moeller
Journal:  J Am Chem Soc       Date:  2012-09-28       Impact factor: 15.419

5.  Pro-oxidative activities and dose-response relationship of (-)-epigallocatechin-3-gallate in the inhibition of lung cancer cell growth: a comparative study in vivo and in vitro.

Authors:  Guang-Xun Li; Yu-Kuo Chen; Zhe Hou; Hang Xiao; Huanyu Jin; Gary Lu; Mao-Jung Lee; Ba Liu; Fei Guan; Zhihong Yang; Albert Yu; Chung S Yang
Journal:  Carcinogenesis       Date:  2010-02-16       Impact factor: 4.944

6.  Anticancer and anti-inflammatory effects of cysteine metabolites of the green tea polyphenol, (-)-epigallocatechin-3-gallate.

Authors:  Joshua D Lambert; Shengmin Sang; Jungil Hong; Chung S Yang
Journal:  J Agric Food Chem       Date:  2010-09-22       Impact factor: 5.279

Review 7.  The challenge of developing green tea polyphenols as therapeutic agents.

Authors:  C Huo; S B Wan; W H Lam; L Li; Z Wang; K R Landis-Piwowar; D Chen; Q P Dou; T H Chan
Journal:  Inflammopharmacology       Date:  2008-10       Impact factor: 4.473

Review 8.  Approaches that ascertain the role of dietary compounds in colonic cancer cells.

Authors:  Michael Bordonaro; Koen Venema; Adeline K Putri; Darina Lazarova
Journal:  World J Gastrointest Oncol       Date:  2014-01-15

9.  Concise Synthesis of Catechin Metabolites 5-(3',4'-Dihydroxyphenyl)-γ-valerolactones (DHPV) in Optically Pure Form and Their Stereochemical Effects on Skin Wrinkle-Reducing Activities.

Authors:  Joonseong Hur; A-Ram Kim; Hyun Su Kim; Changjin Lim; Taewoo Kim; Tae-Aug Kim; Jaehoon Sim; Young-Ger Suh
Journal:  Molecules       Date:  2020-04-23       Impact factor: 4.411

Review 10.  Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases.

Authors:  Daniele Del Rio; Ana Rodriguez-Mateos; Jeremy P E Spencer; Massimiliano Tognolini; Gina Borges; Alan Crozier
Journal:  Antioxid Redox Signal       Date:  2012-08-27       Impact factor: 8.401
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