Literature DB >> 15686618

JAK/STAT signaling regulates tissue outgrowth and male germline stem cell fate in Drosophila.

Shree Ram Singh1, Xiu Chen, Steven X Hou.   

Abstract

In multicellular organisms, biological activities are regulated by cell signaling. The various signal transduction pathways regulate cell fate, proliferation, migration, and polarity. Miscoordination of the communicative signals will lead to disasters like cancer and other fatal diseases. The JAK/STAT signal transduction pathway is one of the pathways, which was first identified in vertebrates and is highly conserved throughout evolution. Studying the JAK/STAT signal transduction pathway in Drosophila provides an excellent opportunity to understand the molecular mechanism of the cell regulation during development and tumor formation. In this review, we discuss the general overview of JAK/STAT signaling in Drosophila with respect to its functions in the eye development and stem cell fate determination.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15686618     DOI： 10.1038/sj.cr.7290255

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  13 in total

Review 1.  The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition.

Authors:  Sylvane Desrivières; Christian Kunz; Itamar Barash; Vida Vafaizadeh; Corina Borghouts; Bernd Groner
Journal:  J Mammary Gland Biol Neoplasia       Date:  2006-01       Impact factor: 2.673

2.  Genetic, immunofluorescence labeling, and in situ hybridization techniques in identification of stem cells in male and female germline niches.

Authors:  Shree Ram Singh; Ying Liu; Madhuri Kango-Singh; Eviatar Nevo
Journal:  Methods Mol Biol       Date:  2013

3.  Transcriptome analysis of BmN cells following over-expression of BmSTAT.

Authors:  Xiaolong Hu; Xi Zhang; Jian Wang; Moli Huang; Renyu Xue; Guangli Cao; Chengliang Gong
Journal:  Mol Genet Genomics       Date:  2015-05-22       Impact factor: 3.291

4.  Competitiveness for the niche and mutual dependence of the germline and somatic stem cells in the Drosophila testis are regulated by the JAK/STAT signaling.

Authors:  Shree Ram Singh; Zhiyu Zheng; Hong Wang; Su-Wan Oh; Xiu Chen; Steven X Hou
Journal:  J Cell Physiol       Date:  2010-05       Impact factor: 6.384

5.  Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development.

Authors:  Yan Zhang; Jia You; Wenyan Ren; Xinhua Lin
Journal:  Dev Biol       Date:  2013-01-08       Impact factor: 3.582

Review 6.  Multipotent stem cells in the Malpighian tubules of adult Drosophila melanogaster.

Authors:  Shree Ram Singh; Steven X Hou
Journal:  J Exp Biol       Date:  2009-02       Impact factor: 3.312

7.  Microarray for genes associated with signal transduction in diabetic OLETF keratocytes.

Authors:  Ji-Eun Lee; Jong Soo Lee; Sang Ho Hwang
Journal:  Korean J Ophthalmol       Date:  2007-06

8.  Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation.

Authors:  Wenyan Ren; Yan Zhang; Min Li; Longfei Wu; Guolun Wang; Gyeong-Hun Baeg; Jia You; Zhouhua Li; Xinhua Lin
Journal:  PLoS Genet       Date:  2015-04-29       Impact factor: 5.917

9.  Maintenance of Stem Cell Niche Integrity by a Novel Activator of Integrin Signaling.

Authors:  Joo Yeun Lee; Jessica Y Chen; Jillian L Shaw; Karen T Chang
Journal:  PLoS Genet       Date:  2016-05-18       Impact factor: 5.917

10.  Selection for female traits of high fertility affects male reproductive performance and alters the testicular transcriptional profile.

Authors:  Marten Michaelis; Alexander Sobczak; Dirk Koczan; Martina Langhammer; Norbert Reinsch; Jennifer Schoen; Joachim M Weitzel
Journal:  BMC Genomics       Date:  2017-11-21       Impact factor: 3.969
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.