Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth.

Literature DB >> 15686343

A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth.

Stacey A Kalovidouris¹, Cristal I Gama, Lori W Lee, Linda C Hsieh-Wilson.

Abstract

We report a fucose alpha(1-2) galactose-mediated pathway for the modulation of neuronal growth and morphology. Our studies provide strong evidence for the presence of Fucalpha(1-2)Gal glycoproteins and lectin receptors in hippocampal neurons. Additionally, we show that manipulation of Fucalpha(1-2)Gal-associated proteins using small-molecule and lectin probes induces dramatic changes in neuronal morphology. These findings may provide a novel pathway to stimulate neuronal growth and regeneration.

Entities: Gene

Mesh：

Substances：

Year: 2005 PMID： 15686343 DOI： 10.1021/ja044631v

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

Keyword Cloud
Cited

17 in total

1. Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons.

Authors: Heather E Murrey; Cristal I Gama; Stacey A Kalovidouris; Wen-I Luo; Edward M Driggers; Barbara Porton; Linda C Hsieh-Wilson
Journal: Proc Natl Acad Sci U S A Date: 2005-12-22 Impact factor: 11.205

Review 2. The chemical neurobiology of carbohydrates.

Authors: Heather E Murrey; Linda C Hsieh-Wilson
Journal: Chem Rev Date: 2008-05-02 Impact factor: 60.622

3. Neoglucosylated collagen matrices drive neuronal cells to differentiate.

Authors: Laura Russo; Antonella Sgambato; Marzia Lecchi; Valentina Pastori; Mario Raspanti; Antonino Natalello; Silvia M Doglia; Francesco Nicotra; Laura Cipolla
Journal: ACS Chem Neurosci Date: 2014-03-19 Impact factor: 4.418

4. Molecular clock regulates daily α1-2-fucosylation of the neural cell adhesion molecule (NCAM) within mouse secondary olfactory neurons.

Authors: Daisuke Kondoh; Hiroaki Tateno; Jun Hirabayashi; Yuki Yasumoto; Reiko Nakao; Katsutaka Oishi
Journal: J Biol Chem Date: 2014-11-10 Impact factor: 5.157

A role for fucose alpha(1-2) galactose carbohydrates in neuronal growth.

1. Protein fucosylation regulates synapsin Ia/Ib expression and neuronal morphology in primary hippocampal neurons.

Review 2. The chemical neurobiology of carbohydrates.

3. Neoglucosylated collagen matrices drive neuronal cells to differentiate.

4. Molecular clock regulates daily α1-2-fucosylation of the neural cell adhesion molecule (NCAM) within mouse secondary olfactory neurons.

5. Characterization of murine brain membrane glycoproteins by detergent assisted lectin affinity chromatography.

Review 6. Biological functions of fucose in mammals.

7. Identification of the plasticity-relevant fucose-alpha(1-2)-galactose proteome from the mouse olfactory bulb.

Review 8. Glycan Engineering for Cell and Developmental Biology.

9. Caged neuron MEA: a system for long-term investigation of cultured neural network connectivity.

10. Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain.