Long-term efficacy and toxicity of the FEC100 regimen.

Adjuvant chemotherapy has been shown to be beneficial in patients with breast cancer, and anthracycline-containing regimens are more effective than non-anthracycline-containing ones. The French Adjuvant Study Group (FASG) compared FEC100 and FEC50 (fluorouracil [5-FU]/epirubicin [Ellence]/cyclophosphamide [Cytoxan, Neosar]) in patients with node-positive breast cancer, with an endpoint of overall survival. After a median follow-up of 10 years, the benefit/risk ratio of the FEC100 regimen in patients with positive axillary nodes is strongly positive. Furthermore, a medicoeconomic study showed that the cost per year of life saved was very low--approximately 1000 Euros.

RCT Entities:   Population Interventions Outcomes