Literature DB >> 1568479

Transforming growth factors type-beta and dexamethasone attenuate group II phospholipase A2 gene expression by interleukin-1 and forskolin in rat mesangial cells.

H Mühl1, T Geiger, W Pignat, F Märki, H van den Bosch, N Cerletti, D Cox, G McMaster, K Vosbeck, J Pfeilschifter.   

Abstract

Treatment of rat mesangial cells with interleukin-1 beta (IL-1 beta) and forskolin induced, in a synergistic fashion, the expression of group II phospholipase A2 (PLA2) mRNA, with subsequent increased synthesis and secretion of PLA2. In contrast, interleukin-6 did not increase PLA2 mRNA levels of PLA2 activity. Transforming growth factor (TGF) beta 1, TGF beta 2 and TGF beta 3 equipotently attenuated the IL-1 beta- and forskolin-induced elevation of PLA2 mRNA, as well as PLA2 synthesis and secretion. The glucocorticoid dexamethasone only partially suppressed the IL-1 beta- and forskolin-induced elevation of PLA2 mRNA, but totally inhibited PLA2 synthesis and secretion.

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Year:  1992        PMID： 1568479     DOI： 10.1016/0014-5793(92)81245-h

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

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2.  Posttranscriptional effect of insulin-like growth factor-I on interleukin-1beta-induced type II-secreted phospholipase A2 gene expression in rabbit articular chondrocytes.

Authors:  C Jacques; G Béréziat; L Humbert; J L Olivier; M T Corvol; J Masliah; F Berenbaum
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3.  Inhibition of NFkappaB-mediated pro-inflammatory gene expression in rat mesangial cells by the enolized 1,3-dioxane-4, 6-dione-5-carboxamide, CGP-43182.

Authors:  K Scholz-Pedretti; W Eberhardt; G Rupprecht; K F Beck; S Spitzer; J Pfeilschifter; M Kaszkin
Journal:  Br J Pharmacol       Date:  2000-07       Impact factor: 8.739

4.  FTY720 suppresses interleukin-1beta-induced secretory phospholipase A2 expression in renal mesangial cells by a transcriptional mechanism.

Authors:  C Xin; S Ren; W Eberhardt; J Pfeilschifter; A Huwiler
Journal:  Br J Pharmacol       Date:  2007-02-26       Impact factor: 8.739

Review 5.  Role of the nitric oxide/cyclic GMP/Ca2+ signaling pathway in the pyrogenic effect of interleukin-1beta.

Authors:  Mitri Palmi; Antonella Meini
Journal:  Mol Neurobiol       Date:  2002-04       Impact factor: 5.590

6.  Elevated expression of human nonpancreatic phospholipase A2 in psoriatic tissue.

Authors:  S Andersen; W Sjursen; A Laegreid; G Volden; B Johansen
Journal:  Inflammation       Date:  1994-02       Impact factor: 4.092

7.  Cell-specific regulation of type II phospholipase A2 expression in rat mesangial cells.

Authors:  M Konieczkowski; J R Sedor
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

8.  Cytokine regulation of group II phospholipase A2 expression in glomerular mesangial cells.

Authors:  J Pfeilschifter; H Mühl; W Pignat; F Märki; H van den Bosch
Journal:  Eur J Clin Pharmacol       Date:  1993       Impact factor: 2.953

9.  Expression of nitric oxide synthase in rat glomerular mesangial cells mediated by cyclic AMP.

Authors:  H Mühl; D Kunz; J Pfeilschifter
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

10.  Effects of dexamethasone and transforming growth factor-beta 2 on group II phospholipase A2 mRNA and activity levels in interleukin 1 beta- and forskolin-stimulated mesangial cells.

Authors:  M J Vervoordeldonk; C G Schalkwijk; J Pfeilschifter; H van den Bosch
Journal:  Biochem J       Date:  1996-04-15       Impact factor: 3.857
  10 in total

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