Literature DB >> 15684564

Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia.

Yoshihisa Kitamura1, Daijiro Yanagisawa, Masatoshi Inden, Kazuyuki Takata, Daiju Tsuchiya, Toshiyuki Kawasaki, Takashi Taniguchi, Shun Shimohama.   

Abstract

The function of microglia in the brain parenchyma is not fully understood. Occlusion of the middle cerebral artery (MCA) and reperfusion caused behavioral dysfunction with massive neuronal loss in the rat cerebral cortex and striatum. When exogenous microglia were microinjected into the intracerebroventricle (i.c.v.) during MCA occlusion, focal ischemia-induced behavioral dysfunction was significantly inhibited. At that time, many microglia migrated into the ischemic lesion, and microglia-derived neuron-like cells were barely detectable. These results suggest that exogenous microglia protect against focal ischemia-induced neurodegeneration and improve behavioral dysfunction.

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Year:  2005        PMID： 15684564     DOI： 10.1254/jphs.sc0040129

Source DB:  PubMed          Journal:  J Pharmacol Sci        ISSN： 1347-8613            Impact factor:   3.337


  21 in total

1.  [Comparison of different methods for drug delivery via the lumbar spinal subarachnoid space in rats].

Authors:  Yanping Zheng; Meng Jiang; Changli Li; Bixiang Yu; Chunqiu Pan; Wangmei Zhou; Pengwei Shi; Peng Huang; Yaoquan He; Shengwu Liao
Journal:  Nan Fang Yi Ke Da Xue Xue Bao       Date:  2019-10-30

2.  Microglia in ischemic brain injury.

Authors:  Jonathan R Weinstein; Ines P Koerner; Thomas Möller
Journal:  Future Neurol       Date:  2010-03-01

3.  Inflammation in adult and neonatal stroke.

Authors:  Zinaida S Vexler; Xian Nan Tang; Midori A Yenari
Journal:  Clin Neurosci Res       Date:  2006-12-01

Review 4.  Microglial voltage-gated proton channel Hv1 in ischemic stroke.

Authors:  Long-Jun Wu
Journal:  Transl Stroke Res       Date:  2013-10-03       Impact factor: 6.829

5.  Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues.

Authors:  Ukpong Eyo; Michael E Dailey
Journal:  Glia       Date:  2012-07-28       Impact factor: 7.452

Review 6.  Microglia: key elements in neural development, plasticity, and pathology.

Authors:  Ukpong B Eyo; Michael E Dailey
Journal:  J Neuroimmune Pharmacol       Date:  2013-01-27       Impact factor: 4.147

7.  P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation.

Authors:  Ukpong B Eyo; Sam A Miner; Katelin E Ahlers; Long-Jun Wu; Michael E Dailey
Journal:  Neuropharmacology       Date:  2013-06-12       Impact factor: 5.250

Review 8.  Role of microglia in ischemic focal stroke and recovery: focus on Toll-like receptors.

Authors:  Jenni E Anttila; Keith W Whitaker; Emily S Wires; Brandon K Harvey; Mikko Airavaara
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2016-07-04       Impact factor: 5.067

9.  Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury.

Authors:  Takashi Yanagida; Jun Tsushima; Yoshihisa Kitamura; Daijiro Yanagisawa; Kazuyuki Takata; Tomonori Shibaike; Atsuko Yamamoto; Takashi Taniguchi; Hiroyuki Yasui; Takahiro Taira; Shigehiro Morikawa; Toshihiro Inubushi; Ikuo Tooyama; Hiroyoshi Ariga
Journal:  Oxid Med Cell Longev       Date:  2009 Jan-Mar       Impact factor: 6.543

10.  Oxidative neurodegeneration is prevented by UCP0045037, an allosteric modulator for the reduced form of DJ-1, a wild-type of familial Parkinson's disease-linked PARK7.

Authors:  Koichiro Yamane; Yoshihisa Kitamura; Takashi Yanagida; Kazuyuki Takata; Daijiro Yanagisawa; Takashi Taniguchi; Takahiro Taira; Hiroyoshi Ariga
Journal:  Int J Mol Sci       Date:  2009-11-05       Impact factor: 6.208
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