Literature DB >> 15684337

Localization of sphingosine kinase-1 in mouse sperm acrosomes.

Kenji Matsumoto1, Yoshiko Banno, Takashi Murate, Yukihiro Akao, Yoshinori Nozawa.   

Abstract

Sphingosine kinase (SPHK) catalyzes sphingosine phosphorylation to form a bioactive lipid mediator, sphingosine-1-phosphate (S1P). In the current study, we report the presence of SPHK-1 in mouse spermatozoa. SPHK-1 was localized to the acrosomes of spermatozoa, and its expression was proven by RT-PCR and Western blot analysis. SPHK activity of mouse spermatozoa was 18.1 pmol/min/mg protein. Furthermore, we identified the presence of the S1P receptors S1P1, S1P2, S1P3, and S1P5, in mouse spermatozoa by RT-PCR. These results suggest that S1P produced by SPHK-1 would play a role in the acrosomal reaction through S1P receptors.

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Year:  2005        PMID： 15684337     DOI： 10.1369/jhc.4B6507.2005

Source DB:  PubMed          Journal:  J Histochem Cytochem        ISSN： 0022-1554            Impact factor:   2.479


  5 in total

Review 1.  Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.

Authors:  Victoria A Blaho; Timothy Hla
Journal:  Chem Rev       Date:  2011-09-22       Impact factor: 60.622

2.  Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides.

Authors:  Toru Takeo; Kiyoko Fukumoto; Tomoko Kondo; Yukie Haruguchi; Yumi Takeshita; Yuko Nakamuta; Shuuji Tsuchiyama; Hidetaka Yoshimoto; Norihiko Shimizu; Ming-Wen Li; Kristy Kinchen; Jadine Vallelunga; K C Kent Lloyd; Naomi Nakagata
Journal:  Cryobiology       Date:  2013-11-04       Impact factor: 2.487

Review 3.  Roles of sphingosine-1-phosphate in reproduction.

Authors:  Lei Guo; Xianghong Ou; Hong Li; Zhiming Han
Journal:  Reprod Sci       Date:  2013-12-13       Impact factor: 3.060

4.  Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosis.

Authors:  Laila Suhaiman; Gerardo A De Blas; Lina M Obeid; Alberto Darszon; Luis S Mayorga; Silvia A Belmonte
Journal:  J Biol Chem       Date:  2010-03-17       Impact factor: 5.157

5.  Protein profiling of testicular tissue from boars with different levels of hyperactive sperm motility.

Authors:  Maren van Son; Dag Inge Våge; Morten Skaugen; Nina Hårdnes Tremoen; Ann Helen Gaustad; Teklu Tewoldebrhan Zeremichael; Frøydis Deinboll Myromslien; Eli Grindflek
Journal:  Acta Vet Scand       Date:  2022-09-05       Impact factor: 2.048
  5 in total

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