Literature DB >> 15684279

Reduction of treatment delay in patients with ST-elevation myocardial infarction: impact of pre-hospital diagnosis and direct referral to primary percutanous coronary intervention.

Christian Juhl Terkelsen1, Jens Flensted Lassen, Bjarne Linde Nørgaard, Jens Christian Gerdes, Steen Hvitfeldt Poulsen, Kristoffer Bendix, Jens Peter Ankersen, Liv Bjørn-Hansen Gøtzsche, Frode Kirketerp Rømer, Torsten Toftegaard Nielsen, Henning Rud Andersen.   

Abstract

AIMS: The majority of patients with ST-elevation myocardial infarction (STEMI) are admitted to local hospitals without primary percutaneous coronary intervention (primary PCI) facilities. Acute transferral to an interventional centre is necessary to treat these patients with primary PCI. The present study assessed the reduction in treatment delay achieved by pre-hospital diagnosis and referral directly to an interventional centre. METHODS AND
RESULTS: Two local hospitals without primary PCI facilities were serving the study region. Pre-hospital diagnoses were established with the use of telemedicine, by ambulance physicians, or by general practitioners. Primary PCI was accepted as the preferred reperfusion therapy in patients with STEMI. From 31 October 2002 to 31 January 2004 all patients transported by ambulance and transferred for primary PCI were registered. Patients with STEMI were divided into three groups: (A) patients diagnosed at a local hospital (n = 55), (B) patients diagnosed pre-hospitally and admitted to a local hospital (n = 85), and (C) patients diagnosed pre-hospitally and referred directly to the interventional centre (n = 21). When comparing group A with group B and C, no difference was found in age, sex, infarct location, or distance from the scene of event to the interventional centre, whereas the median time from ambulance call to first balloon inflation was 41 min shorter in group B compared with group A (P<0.001) and 81 min shorter in group C compared with group A (P<0.001).
CONCLUSION: In a cohort of patients scheduled for admission to a local hospital and subsequent transferral to an interventional centre for primary PCI, those diagnosed pre-hospitally had shorter treatment delay compared with those diagnosed in hospital, both in the setting of initial admission to a local hospital, and to an even larger extent in the setting of referral directly to the interventional centre.

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Mesh:

Year:  2005        PMID: 15684279     DOI: 10.1093/eurheartj/ehi100

Source DB:  PubMed          Journal:  Eur Heart J        ISSN: 0195-668X            Impact factor:   29.983


  31 in total

1.  Ambulance diagnosis of ST elevation myocardial infarction eligible for primary PCI.

Authors:  F W A Verheugt
Journal:  Neth Heart J       Date:  2008       Impact factor: 2.380

2.  Treatment delays in ST elevation myocardial infarction.

Authors:  Christian Juhl Terkelsen; Jens Flensted Lassen
Journal:  BMJ       Date:  2008-02-23

Review 3.  Reperfusion options in ST-elevation myocardial infarction patients with expected delays.

Authors:  David M Larson; Timothy D Henry
Journal:  Curr Cardiol Rep       Date:  2008-09       Impact factor: 2.931

Review 4.  Timely and optimal treatment of patients with STEMI.

Authors:  Jens F Lassen; Hans E Bøtker; Christian J Terkelsen
Journal:  Nat Rev Cardiol       Date:  2012-11-20       Impact factor: 32.419

Review 5.  Timely reperfusion for ST-segment elevation myocardial infarction: Effect of direct transfer to primary angioplasty on time delays and clinical outcomes.

Authors:  Rodrigo Estévez-Loureiro; Angela López-Sainz; Armando Pérez de Prado; Carlos Cuellas; Ramón Calviño Santos; Norberto Alonso-Orcajo; Jorge Salgado Fernández; Jose Manuel Vázquez-Rodríguez; Maria López-Benito; Felipe Fernández-Vázquez
Journal:  World J Cardiol       Date:  2014-06-26

6.  Time to treatment-door-to-balloon time is not everything.

Authors:  C J Terkelsen
Journal:  Herz       Date:  2014-09       Impact factor: 1.443

7.  Bypassing the emergency room reduces delays and mortality in ST elevation myocardial infarction: the USIC 2000 registry.

Authors:  P G Steg; J-P Cambou; P Goldstein; E Durand; P Sauval; Z Kadri; D Blanchard; J-M Lablanche; P Guéret; Y Cottin; J-M Juliard; G Hanania; L Vaur; N Danchin
Journal:  Heart       Date:  2006-08-16       Impact factor: 5.994

8.  Conditions mimicking acute ST-segment elevation myocardial infarction in patients referred for primary percutaneous coronary intervention.

Authors:  Y L Gu; T Svilaas; I C C van der Horst; F Zijlstra
Journal:  Neth Heart J       Date:  2008-10       Impact factor: 2.380

Review 9.  Role of nitric oxide in the functional response to ischemia-reperfusion of heart mitochondria from hyperthyroid rats.

Authors:  P Venditti; R De Rosa; L Cigliano; C Agnisola; S Di Meo
Journal:  Cell Mol Life Sci       Date:  2004-09       Impact factor: 9.261

Review 10.  Early identification and delay to treatment in myocardial infarction and stroke: differences and similarities.

Authors:  Johan Herlitz; Birgitta Wireklintsundström; Angela Bång; Annika Berglund; Leif Svensson; Christian Blomstrand
Journal:  Scand J Trauma Resusc Emerg Med       Date:  2010-09-06       Impact factor: 2.953

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