BACKGROUND: Few investigations have examined the impact of childhood trauma, and domains of childhood abuse, on outcome in bipolar disorder. AIMS: To evaluate the prevalence and subtypes of childhood abuse reported by adult patients with bipolar disorder and relationship to clinical outcome. METHOD: Prevalence rates of childhood abuse were retrospectively assessed and examined relative to illness complexity in a sample of 100 patients at an academic specialty centre for the treatment of bipolar disorder. RESULTS: Histories of severe childhood abuse were identified in about half of the sample and were associated with early age at illness onset. Abuse subcategories were strongly inter-related. Severe emotional abuse was significantly associated with lifetime substance misuse comorbidity and past-year rapid cycling. Logistic regression indicated a significant association between lifetime suicide attempts and severe childhood sexual abuse. Multiple forms of abuse showed a graded increase in risk for both suicide attempts and rapid cycling. CONCLUSIONS: Severe childhood trauma appears to have occurred in about half of patients with bipolar disorder, and may lead to more complex psychopathological manifestations.
BACKGROUND: Few investigations have examined the impact of childhood trauma, and domains of childhood abuse, on outcome in bipolar disorder. AIMS: To evaluate the prevalence and subtypes of childhood abuse reported by adult patients with bipolar disorder and relationship to clinical outcome. METHOD: Prevalence rates of childhood abuse were retrospectively assessed and examined relative to illness complexity in a sample of 100 patients at an academic specialty centre for the treatment of bipolar disorder. RESULTS: Histories of severe childhood abuse were identified in about half of the sample and were associated with early age at illness onset. Abuse subcategories were strongly inter-related. Severe emotional abuse was significantly associated with lifetime substance misuse comorbidity and past-year rapid cycling. Logistic regression indicated a significant association between lifetime suicide attempts and severe childhood sexual abuse. Multiple forms of abuse showed a graded increase in risk for both suicide attempts and rapid cycling. CONCLUSIONS: Severe childhood trauma appears to have occurred in about half of patients with bipolar disorder, and may lead to more complex psychopathological manifestations.
Authors: Amit Anand; Daniel L Koller; William B Lawson; Elliot S Gershon; John I Nurnberger Journal: J Affect Disord Date: 2015-03-10 Impact factor: 4.839
Authors: Andrew D Thompson; Barnaby Nelson; Hok Pan Yuen; Ashleigh Lin; Günter Paul Amminger; Patrick D McGorry; Stephen J Wood; Alison R Yung Journal: Schizophr Bull Date: 2013-03-02 Impact factor: 9.306
Authors: Maria Andreu Pascual; Jessica C Levenson; John Merranko; Mary Kay Gill; Heather Hower; Shirley Yen; Michael Strober; Tina R Goldstein; Benjamin I Goldstein; Neal D Ryan; Lauren M Weinstock; Martin B Keller; David Axelson; Boris Birmaher Journal: J Affect Disord Date: 2020-05-22 Impact factor: 4.839