BACKGROUND AND AIMS: The immunogenetic basis of autoimmune diseases has become more and more evident. We have analyzed the human leukocyte antigen (HLA) associations with type-1 autoimmune hepatitis (AIH) among patients from western India. METHODS: In 20 patients and 120 healthy controls, polymerase chain reaction amplified with sequence specific primers and hybridized with oligoprobes was carried out to elucidate the HLA A, B, C and DRB1 allele associations. RESULTS: The study revealed that A*0222 (20% vs 1.66%; P = 0.0001), A*3201 (15% vs 0.83%; P = 0.0004), A*680102 (30% vs 6.66%; P = 0.001), B*35 (40% vs 11.66%; P = 0.001), B*5501 (10% vs 0.83%; P = 0.008), Cw*0102 (15% vs 1.66%; P = 0.002) and Cw*070101 (50% vs 11.66%; P = 2.5E-05) were significantly increased among the A, B and C alleles of AIH patients. Among the HLA DRB1 alleles, DRB1*0301 (20% vs 6.19%; P = 0.03), DRB1*1301 (15% vs 2.65%; P = 0.01), DRB1*14 (30% vs 11.5%; P = 0.02) and DRB1*1501 (40% vs 22.12%; P = 0.08) were increased in AIH patients when compared with the controls. CONCLUSIONS: The present study indicates that the HLA susceptibility to type 1 AIH in the different populations studied is complex. (c) 2004 Blackwell Publishing Asia Pty Ltd.
BACKGROUND AND AIMS: The immunogenetic basis of autoimmune diseases has become more and more evident. We have analyzed the human leukocyte antigen (HLA) associations with type-1 autoimmune hepatitis (AIH) among patients from western India. METHODS: In 20 patients and 120 healthy controls, polymerase chain reaction amplified with sequence specific primers and hybridized with oligoprobes was carried out to elucidate the HLA A, B, C and DRB1 allele associations. RESULTS: The study revealed that A*0222 (20% vs 1.66%; P = 0.0001), A*3201 (15% vs 0.83%; P = 0.0004), A*680102 (30% vs 6.66%; P = 0.001), B*35 (40% vs 11.66%; P = 0.001), B*5501 (10% vs 0.83%; P = 0.008), Cw*0102 (15% vs 1.66%; P = 0.002) and Cw*070101 (50% vs 11.66%; P = 2.5E-05) were significantly increased among the A, B and C alleles of AIH patients. Among the HLA DRB1 alleles, DRB1*0301 (20% vs 6.19%; P = 0.03), DRB1*1301 (15% vs 2.65%; P = 0.01), DRB1*14 (30% vs 11.5%; P = 0.02) and DRB1*1501 (40% vs 22.12%; P = 0.08) were increased in AIH patients when compared with the controls. CONCLUSIONS: The present study indicates that the HLA susceptibility to type 1 AIH in the different populations studied is complex. (c) 2004 Blackwell Publishing Asia Pty Ltd.
Authors: Mark H Kuniholm; Andrea Kovacs; Xiaojiang Gao; Xiaonan Xue; Darlene Marti; Chloe L Thio; Marion G Peters; Norah A Terrault; Ruth M Greenblatt; James J Goedert; Mardge H Cohen; Howard Minkoff; Stephen J Gange; Kathryn Anastos; Melissa Fazzari; Tiffany G Harris; Mary A Young; Howard D Strickler; Mary Carrington Journal: Hepatology Date: 2010-05 Impact factor: 17.425
Authors: Andreas Teufel; Markus Wörns; Arndt Weinmann; Catherine Centner; Anja Piendl; Ansgar W Lohse; Peter R Galle; Stephan Kanzler Journal: World J Gastroenterol Date: 2006-09-14 Impact factor: 5.742