Literature DB >> 1568249

Yeast Sec proteins interact with polypeptides traversing the endoplasmic reticulum membrane.

A Müsch1, M Wiedmann, T A Rapoport.   

Abstract

We show by photocross-linking that nascent secretory proteins, during their passage through the endoplasmic reticulum membrane of S. cerevisiae, are in physical contact with Sec61p and Sec62p, two genetically identified membrane proteins that are essential for in vivo translocation. Sec61p seems to be in continuous contact, whereas Sec62p is involved only transiently. Translocation comprises both ATP-dependent and -independent phases of interaction with the Sec proteins. The results suggest a direct role of the Sec proteins in translocation.

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Year:  1992        PMID： 1568249     DOI： 10.1016/0092-8674(92)90414-8

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  47 in total

1.  A plastid enzyme arrested in the step of precursor translocation in vivo.

Authors:  S Reinbothe; C Reinbothe; D Neumann; K Apel
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

2.  In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation.

Authors:  R G Gardner; A G Shearer; R Y Hampton
Journal:  Mol Cell Biol       Date:  2001-07       Impact factor: 4.272

3.  Interactions between Sec complex and prepro-alpha-factor during posttranslational protein transport into the endoplasmic reticulum.

Authors:  Kathrin Plath; Barrie M Wilkinson; Colin J Stirling; Tom A Rapoport
Journal:  Mol Biol Cell       Date:  2003-11-14       Impact factor: 4.138

4.  Oligosaccharyltransferase directly binds to ribosome at a location near the translocon-binding site.

Authors:  Yoichiro Harada; Hua Li; Huilin Li; William J Lennarz
Journal:  Proc Natl Acad Sci U S A       Date:  2009-04-13       Impact factor: 11.205

5.  The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome-nascent chain complex.

Authors:  C Pfund; N Lopez-Hoyo; T Ziegelhoffer; B A Schilke; P Lopez-Buesa; W A Walter; M Wiedmann; E A Craig
Journal:  EMBO J       Date:  1998-07-15       Impact factor: 11.598

6.  Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation.

Authors:  M Pilon; R Schekman; K Römisch
Journal:  EMBO J       Date:  1997-08-01       Impact factor: 11.598

Review 7.  Crosslinking and Reconstitution Approaches to Study Protein Transport.

Authors:  Andreas Kuhn
Journal:  Protein J       Date:  2019-06       Impact factor: 2.371

8.  cDNA cloning of a Sec61 homologue from the cryptomonad alga Pyrenomonas salina.

Authors:  S B Müller; S A Rensing; W F Martin; U G Maier
Journal:  Curr Genet       Date:  1994 Nov-Dec       Impact factor: 3.886

9.  The Srp54 GTPase is essential for protein export in the fission yeast Schizosaccharomyces pombe.

Authors:  S M Althoff; S W Stevens; J A Wise
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

10.  Genetic interactions between KAR2 and SEC63, encoding eukaryotic homologues of DnaK and DnaJ in the endoplasmic reticulum.

Authors:  M A Scidmore; H H Okamura; M D Rose
Journal:  Mol Biol Cell       Date:  1993-11       Impact factor: 4.138
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