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Literature DB >> 15681612

Frat is dispensable for canonical Wnt signaling in mammals.

Renée van Amerongen¹, Martijn Nawijn, Jonathan Franca-Koh, John Zevenhoven, Hanneke van der Gulden, Jos Jonkers, Anton Berns.

Abstract

Wnt-signal transduction through beta-catenin is thought to require the inhibition of GSK3 by Frat/GBP. To investigate the role of Frat in mammalian development, we have generated mice with targeted mutations in all three murine Frat homologs. We show that Frat is normally expressed at sites of active Wnt signaling. Surprisingly, Frat-deficient mice do not display gross abnormalities. Moreover, canonical Wnt signaling in primary cells is unaffected by the loss of Frat. These studies show that Frat is not an essential component of the canonical Wnt pathway in higher organisms, despite the strict requirement of Frat/GBP for maternal Wnt signaling in Xenopus.

Entities: Gene Species

Mesh：

Substances：

Year: 2005 PMID： 15681612 PMCID： PMC548942 DOI： 10.1101/gad.326705

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

37 in total

1. The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP.

Authors: Jonathan Franca-Koh; Margaret Yeo; Elizabeth Fraser; Neville Young; Trevor C Dale
Journal: J Biol Chem Date: 2002-09-09 Impact factor: 5.157

2. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.

Authors: Eduard Batlle; Jeffrey T Henderson; Harry Beghtel; Maaike M W van den Born; Elena Sancho; Gerwin Huls; Jan Meeldijk; Jennifer Robertson; Marc van de Wetering; Tony Pawson; Hans Clevers
Journal: Cell Date: 2002-10-18 Impact factor: 41.582

3. The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

Authors: B Bax; P S Carter; C Lewis; A R Guy; A Bridges; R Tanner; G Pettman; C Mannix; A A Culbert; M J Brown; D G Smith; A D Reith
Journal: Structure Date: 2001-12 Impact factor: 5.006

4. Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription.

Authors: F J Staal; J Meeldijk; P Moerer; P Jay; B C van de Weerdt; S Vainio; G P Nolan; H Clevers
Journal: Eur J Immunol Date: 2001-01 Impact factor: 5.532

5. Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin.

Authors: Denise M Ferkey; David Kimelman
Journal: J Biol Chem Date: 2002-02-22 Impact factor: 5.157

6. Tcf/Lef transcription factors during T-cell development: unique and overlapping functions.

Authors: F J Staal; H Clevers
Journal: Hematol J Date: 2000

7. Molecular cloning and expression of proto-oncogene FRAT1 in human cancer.

Authors: Tetsuroh Saitoh; Tetsuya Mine; Masaru Katoh
Journal: Int J Oncol Date: 2002-04 Impact factor: 5.650

8. Wnt signaling controls the phosphorylation status of beta-catenin.

Authors: Mascha van Noort; Jan Meeldijk; Ruurd van der Zee; Olivier Destree; Hans Clevers
Journal: J Biol Chem Date: 2002-02-07 Impact factor: 5.157

9. Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.

Authors: Sarah J Freemantle; Holly B Portland; Katherine Ewings; Florence Dmitrovsky; Keith DiPetrillo; Michael J Spinella; Ethan Dmitrovsky
Journal: Gene Date: 2002-05-29 Impact factor: 3.688

10. Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.

Authors: Rana Dajani; Elizabeth Fraser; S Mark Roe; Maggie Yeo; Valerie M Good; Vivienne Thompson; Trevor C Dale; Laurence H Pearl
Journal: EMBO J Date: 2003-02-03 Impact factor: 11.598

22 in total

1. Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells.

Authors: Matthew Bechard; Robert Trost; Amar M Singh; Stephen Dalton
Journal: Mol Cell Biol Date: 2011-11-07 Impact factor: 4.272

Frat is dispensable for canonical Wnt signaling in mammals.

1. The regulation of glycogen synthase kinase-3 nuclear export by Frat/GBP.

2. Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB.

3. The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.

4. Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription.

5. Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin.

6. Tcf/Lef transcription factors during T-cell development: unique and overlapping functions.

7. Molecular cloning and expression of proto-oncogene FRAT1 in human cancer.

8. Wnt signaling controls the phosphorylation status of beta-catenin.

9. Characterization and tissue-specific expression of human GSK-3-binding proteins FRAT1 and FRAT2.

10. Structural basis for recruitment of glycogen synthase kinase 3beta to the axin-APC scaffold complex.

1. Frat is a phosphatidylinositol 3-kinase/Akt-regulated determinant of glycogen synthase kinase 3β subcellular localization in pluripotent cells.

Review 2. Signaling in cell differentiation and morphogenesis.

3. Overexpression of Frat1 correlates with malignant phenotype and advanced stage in human non-small cell lung cancer.

Review 4. Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.

Review 5. Wnt signaling in vertebrate axis specification.

Review 6. What does genetics tell us about imprinting and the placenta connection?

Review 7. Intracellular control of developmental and regenerative axon growth.

8. The clinical pathological significance of FRAT1 and ROR2 expression in cartilage tumors.

Review 9. The way Wnt works: components and mechanism.

10. Recommendations for the investigation of animal models of Prader-Willi syndrome.