Literature DB >> 15681407

Role of CCL11 in eosinophilic lung disease during respiratory syncytial virus infection.

Stephen P Matthews1, John S Tregoning, Anthony J Coyle, Tracy Hussell, Peter J M Openshaw.   

Abstract

Respiratory syncytial virus (RSV) is a major viral pathogen of infants and the elderly. Significant morbidity is caused by an overexuberant mixed lung cell infiltrate, which is thought to be driven by chemokines. One of the main chemotactic mediators responsible for the movement of eosinophils is CCL11 (eotaxin). Using a mouse model of eosinophilic bronchiolitis induced by RSV, we show here that treatment in vivo with a blocking antibody to CCL11 greatly reduces lung eosinophilia and disease severity. In addition, anti-CCL11 caused a striking inhibition of CD4-T-cell influx and shifted cytokine production away from interleukin-5 without reducing the resistance to viral replication. These results suggest that in addition to influencing eosinophil diapedesis and survival, anti-CCL11 has an action on T cells. These studies strengthen the case for anti-CCL11 treatment of Th2-driven diseases.

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Year:  2005        PMID： 15681407      PMCID： PMC546549          DOI： 10.1128/JVI.79.4.2050-2057.2005

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  41 in total

Review 1.  Epidemiologic and clinical evidence of a respiratory syncytial virus-reactive airway disease link.

Authors:  N Sigurs
Journal:  Am J Respir Crit Care Med       Date:  2001-03       Impact factor: 21.405

2.  Chemokine production by the BEAS-2B human bronchial epithelial cells: differential regulation of eotaxin, IL-8, and RANTES by TH2- and TH1-derived cytokines.

Authors:  T Fujisawa; Y Kato; J Atsuta; A Terada; K Iguchi; H Kamiya; H Yamada; T Nakajima; M Miyamasu; K Hirai
Journal:  J Allergy Clin Immunol       Date:  2000-01       Impact factor: 10.793

3.  Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo.

Authors:  A de Lavareille; F Roufosse; L Schandené; P Stordeur; E Cogan; M Goldman
Journal:  Eur J Immunol       Date:  2001-04       Impact factor: 5.532

4.  Inducible expression of inflammatory chemokines in respiratory syncytial virus-infected mice: role of MIP-1alpha in lung pathology.

Authors:  H A Haeberle; W A Kuziel; H J Dieterich; A Casola; Z Gatalica; R P Garofalo
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

5.  Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5.

Authors:  P Ogilvie; G Bardi; I Clark-Lewis; M Baggiolini; M Uguccioni
Journal:  Blood       Date:  2001-04-01       Impact factor: 22.113

6.  Influenza virus A stimulates expression of eotaxin by nasal epithelial cells.

Authors:  M Kawaguchi; F Kokubu; H Kuga; T Tomita; S Matsukura; H Suzaki; S K Huang; M Adachi
Journal:  Clin Exp Allergy       Date:  2001-06       Impact factor: 5.018

7.  Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years.

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Journal:  Lancet       Date:  1999-08-14       Impact factor: 79.321

8.  Bronchiolitis-associated mortality and estimates of respiratory syncytial virus-associated deaths among US children, 1979-1997.

Authors:  D K Shay; R C Holman; G E Roosevelt; M J Clarke; L J Anderson
Journal:  J Infect Dis       Date:  2000-11-10       Impact factor: 5.226

9.  Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology.

Authors:  G Walzl; S Matthews; S Kendall; J C Gutierrez-Ramos; A J Coyle; P J Openshaw; T Hussell
Journal:  J Exp Med       Date:  2001-04-02       Impact factor: 14.307

10.  Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice.

Authors:  S W Chensue; N W Lukacs; T Y Yang; X Shang; K A Frait; S L Kunkel; T Kung; M T Wiekowski; J A Hedrick; D N Cook; A Zingoni; S K Narula; A Zlotnik; F J Barrat; A O'Garra; M Napolitano; S A Lira
Journal:  J Exp Med       Date:  2001-03-05       Impact factor: 14.307
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  29 in total

1.  Respiratory syncytial virus F and G proteins induce interleukin 1alpha, CC, and CXC chemokine responses by normal human bronchoepithelial cells.

Authors:  Christine M Oshansky; James P Barber; Jackelyn Crabtree; Ralph A Tripp
Journal:  J Infect Dis       Date:  2010-04-15       Impact factor: 5.226

2.  Overcoming T cell-mediated immunopathology to achieve safe RSV vaccination.

Authors:  Elaine M Castilow; Steven M Varga
Journal:  Future Virol       Date:  2008       Impact factor: 1.831

3.  The role of T cells in the enhancement of respiratory syncytial virus infection severity during adult reinfection of neonatally sensitized mice.

Authors:  John S Tregoning; Yuko Yamaguchi; James Harker; Belinda Wang; Peter J M Openshaw
Journal:  J Virol       Date:  2008-02-13       Impact factor: 5.103

Review 4.  The host response and molecular pathogenesis associated with respiratory syncytial virus infection.

Authors:  Christine M Oshansky; Wenliang Zhang; Elizabeth Moore; Ralph A Tripp
Journal:  Future Microbiol       Date:  2009-04       Impact factor: 3.165

Review 5.  Pulmonary immunity and immunopathology: lessons from respiratory syncytial virus.

Authors:  Matthew R Olson; Steven M Varga
Journal:  Expert Rev Vaccines       Date:  2008-10       Impact factor: 5.217

6.  Autophagy-inducing protein beclin-1 in dendritic cells regulates CD4 T cell responses and disease severity during respiratory syncytial virus infection.

Authors:  Michelle Reed; Susan H Morris; Sihyug Jang; Sumanta Mukherjee; Zhenyu Yue; Nicholas W Lukacs
Journal:  J Immunol       Date:  2013-07-26       Impact factor: 5.422

Review 7.  Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology.

Authors:  John S Tregoning; Jürgen Schwarze
Journal:  Clin Microbiol Rev       Date:  2010-01       Impact factor: 26.132

8.  Pulmonary eosinophilia requires interleukin-5, eotaxin-1, and CD4+ T cells in mice immunized with respiratory syncytial virus G glycoprotein.

Authors:  Teresa R Johnson; Marc E Rothenberg; Barney S Graham
Journal:  J Leukoc Biol       Date:  2008-06-02       Impact factor: 4.962

9.  The number of respiratory syncytial virus (RSV)-specific memory CD8 T cells in the lung is critical for their ability to inhibit RSV vaccine-enhanced pulmonary eosinophilia.

Authors:  Matthew R Olson; Stacey M Hartwig; Steven M Varga
Journal:  J Immunol       Date:  2008-12-01       Impact factor: 5.422

10.  Evidence of a causal role of winter virus infection during infancy in early childhood asthma.

Authors:  Pingsheng Wu; William D Dupont; Marie R Griffin; Kecia N Carroll; Edward F Mitchel; Tebeb Gebretsadik; Tina V Hartert
Journal:  Am J Respir Crit Care Med       Date:  2008-09-05       Impact factor: 21.405
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