Literature DB >> 15681275

Dynamic modeling of complex biological systems: a link between metabolic and macroscopic description.

Jens E Haag1, Alain Vande Wouwer, Philippe Bogaerts.   

Abstract

In this study, a class of dynamic models based on metabolic reaction pathways is analyzed, showing that systems with complex intracellular reaction networks can be represented by macroscopic reactions relating extracellular components only. Based on rigorous assumptions, the model reduction procedure is systematic and allows an equivalent 'input-output' representation of the system to be derived. The procedure is illustrated with a few examples.

Mesh:

Year:  2004        PMID: 15681275     DOI: 10.1016/j.mbs.2004.11.007

Source DB:  PubMed          Journal:  Math Biosci        ISSN: 0025-5564            Impact factor:   2.144


  2 in total

1.  Metabolic design of macroscopic bioreaction models: application to Chinese hamster ovary cells.

Authors:  A Provost; G Bastin; S N Agathos; Y-J Schneider
Journal:  Bioprocess Biosyst Eng       Date:  2006-09-30       Impact factor: 3.210

2.  A unified multiscale field/network/agent based modeling framework for human and ecological health risk analysis.

Authors:  Panos G Georgopoulos; Sastry S Isukapalli
Journal:  Conf Proc IEEE Eng Med Biol Soc       Date:  2009
  2 in total

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