AIMS: To evaluate the levels of endogenous interferon-gamma (IFN-gamma) in patients with familial Mediterranean fever (FMF). METHODS: Plasma levels of IFN-gamma were assayed in 29 FMF patients in attack-free period (mean age: 32, min-max: 17-48; male/female: 10/19), 18 FMF patients with acute FMF attack (mean age: 32, min-max: 19-50; male/female: 8/10), and 19 healthy controls (mean age: 31.94 +/- 1.50, min-max: 23-42; male/female: 11/8). IFN-gamma levels were also compared among colchicine treated and untreated groups. RESULTS: Median plasma IFN-gamma levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-gamma levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-gamma were comparable in colchicine treated and untreated groups. CONCLUSION: Our results suggest that IFN-gamma may contribute to the inflammatory cascade of FMF.
AIMS: To evaluate the levels of endogenous interferon-gamma (IFN-gamma) in patients with familial Mediterranean fever (FMF). METHODS: Plasma levels of IFN-gamma were assayed in 29 FMFpatients in attack-free period (mean age: 32, min-max: 17-48; male/female: 10/19), 18 FMFpatients with acute FMF attack (mean age: 32, min-max: 19-50; male/female: 8/10), and 19 healthy controls (mean age: 31.94 +/- 1.50, min-max: 23-42; male/female: 11/8). IFN-gamma levels were also compared among colchicine treated and untreated groups. RESULTS: Median plasma IFN-gamma levels were significantly higher in patients both with and without FMF attack than the control group (P < 0.05). Moreover, plasma IFN-gamma levels were higher in patients with acute FMF attack compared to patients in attack-free periods (P < 0.05). Plasma levels of IFN-gamma were comparable in colchicine treated and untreated groups. CONCLUSION: Our results suggest that IFN-gamma may contribute to the inflammatory cascade of FMF.
Authors: Muhammet Murat Celik; Eyup Buyukkaya; Nilgul Ustun; Alper Bugra Nacar; Mustafa Kurt; Mehmet Fatih Karakas; Perihan Bilen; Mehmet Duru; Nihat Sen; Adnan Burak Akcay Journal: Wien Klin Wochenschr Date: 2015-03-19 Impact factor: 1.704
Authors: Bunyamin Kisacik; Suheyla Uzun Kaya; Yavuz Pehlivan; Turker Tasliyurt; Mehmet Sayarlioglu; Ahmet Mesut Onat Journal: Rheumatol Int Date: 2011-12-21 Impact factor: 2.631
Authors: Yusuf Tavil; Kemal Ureten; Mehmet Akif Oztürk; Nihat Sen; Mehmet Güngör Kaya; Mustafa Cemri; Atiye Cengel Journal: Clin Rheumatol Date: 2007-07-24 Impact factor: 2.980