Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 PP2A-dependent transactivation of the cyclin A promoter by SV40 ST is mediated by a cell cycle-regulated E2F site.

Literature DB >> 15680424

PP2A-dependent transactivation of the cyclin A promoter by SV40 ST is mediated by a cell cycle-regulated E2F site.

Christine Skoczylas¹, Berthold Henglein, Kathleen Rundell.

Abstract

The Simian Virus 40 (SV40) small-t antigen (ST) plays an important role in driving cell proliferation, enhancing transformation by the large-T (LT) antigen. Potential targets of ST are the cyclin kinase inhibitor p27 and the cyclin A gene itself. Transactivation of the cyclin A promoter by ST depends on the interaction of ST with protein phosphatase 2A (PP2A) and occurs through a cell cycle-regulated E2F site near the transcription start site of the promoter. A third SV40 early protein, 17KT, also transactivates the cyclin A promoter but, in this case, transactivation depends on the dnaJ domain of the protein.

Entities: Species

Mesh：

Substances：

Year: 2005 PMID： 15680424 DOI： 10.1016/j.virol.2004.12.017

Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616

Keyword Cloud
Cited

8 in total

1. Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.

Authors: Shaida Andrabi; Justin H Hwang; Jennifer Kean Choe; Thomas M Roberts; Brian S Schaffhausen
Journal: J Virol Date: 2011-08-10 Impact factor: 5.103

2. PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen.

Authors: S Kotadia; L R Kao; S A Comerford; R T Jones; R E Hammer; T L Megraw
Journal: Oncogene Date: 2008-07-28 Impact factor: 9.867

3. Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E.

Authors: Elena Sotillo; Judit Garriga; Amol Padgaonkar; Alison Kurimchak; Jeanette Gowen Cook; Xavier Graña
Journal: J Biol Chem Date: 2009-03-25 Impact factor: 5.157

4. Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.

Authors: Dohun Pyeon; Michael A Newton; Paul F Lambert; Johan A den Boon; Srikumar Sengupta; Carmen J Marsit; Craig D Woodworth; Joseph P Connor; Thomas H Haugen; Elaine M Smith; Karl T Kelsey; Lubomir P Turek; Paul Ahlquist
Journal: Cancer Res Date: 2007-05-15 Impact factor: 12.701

5. Polyomavirus small T antigen controls viral chromatin modifications through effects on kinetics of virus growth and cell cycle progression.

Authors: Jean Dahl; H Isaac Chen; Michael George; Thomas L Benjamin
Journal: J Virol Date: 2007-07-11 Impact factor: 5.103

PP2A-dependent transactivation of the cyclin A promoter by SV40 ST is mediated by a cell cycle-regulated E2F site.

1. Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.

2. PP2A-dependent disruption of centrosome replication and cytoskeleton organization in Drosophila by SV40 small tumor antigen.

3. Coordinated activation of the origin licensing factor CDC6 and CDK2 in resting human fibroblasts expressing SV40 small T antigen and cyclin E.

4. Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers.

5. Polyomavirus small T antigen controls viral chromatin modifications through effects on kinetics of virus growth and cell cycle progression.

Review 6. Human Polyomaviruses: The Battle of Large and Small Tumor Antigens.

Review 7. Association Between Simian Virus 40 and Human Tumors.

Review 8. Drosophila as a Model for Infectious Diseases.