| Literature DB >> 15680399 |
Doris Polgar1, Christina Leisser, Susanne Maier, Stephan Strasser, Beate Rüger, Markus Dettke, Maya Khorchide, Ingrid Simonitsch, Christa Cerni, Georg Krupitza.
Abstract
The chromosomal translocation t(2;5)(p23;q35) is associated with "Anaplastic large cell lymphomas" (ALCL), a Non Hodgkin Lymphoma occurring in childhood. The fusion of the tyrosine kinase gene-ALK (anaplastic lymphoma kinase) on chromosome 2p23 to the NPM (nucleophosmin/B23) gene on chromosome 5q35 results in a 80 kDa chimeric protein, which activates the "survival" kinase PI3K. However, the binding mechanism between truncated ALK and PI3K is poorly understood. Therefore, we attempted to elucidate the molecular interaction between ALK and the regulatory p85 subunit of PI3K. Here we provide evidence that the truncated ALK homodimer binds to the SH3 domain of p85. This finding may be useful for the development of a new target-specific intervention.Entities:
Mesh：
Substances：
Year: 2005 PMID： 15680399 DOI： 10.1016/j.mrfmmm.2004.09.011
Source DB: PubMed Journal: Mutat Res ISSN： 0027-5107 Impact factor: 2.433