| Literature DB >> 15679144 |
D H Marchand1, K Croes, J W Dolan, L R Snyder, R A Henry, K M R Kallury, S Waite, P W Carr.
Abstract
As reported previously, five solute-column interactions (hydrophobicity, steric resistance, hydrogen-bond acidity and basicity, ionic interaction) quantitatively describe column selectivity for 163 alkyl-silica, polar-group and cyano columns. In the present study, solute retention and column selectivity for 11 phenyl and 5 fluoro-substituted columns were compared with alkyl-silica columns of similar ligand length. It is concluded that two additional solute-column interactions may be significant in affecting retention and selectivity for the latter columns: (a) dispersion interactions of varying strength as a result of significant differences in bonded-phase polarizability or refractive index and (b) pi-pi interactions in the case of phenyl columns and aromatic solutes. These 16 phenyl and fluoro columns were also characterized in terms of hydrophobicity, steric resistance, hydrogen-bond acidity and basicity, and ionic interaction.Entities:
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Year: 2005 PMID： 15679144 DOI： 10.1016/j.chroma.2004.11.014
Source DB: PubMed Journal: J Chromatogr A ISSN： 0021-9673 Impact factor: 4.759