Literature DB >> 1567909

Inhibition of lipoxygenase activity and HL60 leukemic cell proliferation by ursolic acid isolated from heather flowers (Calluna vulgaris).

A Simon1, A Najid, A J Chulia, C Delage, M Rigaud.   

Abstract

A compound was isolated and purified from heather flowers (Calluna vulgaris) based on its ability to inhibit lipoxygenase activity. This molecule was characterized as ursolic acid by GC-MS. Ursolic acid was found to be an inhibitor of both potato tuber 5-lipoxygenase and soybean 15-lipoxygenase with IC50 values of 0.3 mM. Ursolic acid also inhibits lipoxygenase activity in mouse peritoneal macrophages at 1 microM and HL60 leukemic cells growth (IC50 = 0.85 microM) as well as their DNA synthesis (IC50 = 1 microM). The possible role of lipoxygenase inhibition in the proliferation of leukemic cells is discussed.

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Year:  1992        PMID： 1567909     DOI： 10.1016/0005-2760(92)90157-q

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  7 in total

1.  Role of ursolic acid chalcone, a synthetic analogue of ursolic acid, in inhibiting the properties of CD133(+) sphere-forming cells in liver stem cells.

Authors:  Rui-Xin Lin; Lu-Lu Gong; Li-Mei Fan; Zhong-Kai Zhao; Shu-Li Yang
Journal:  Int J Clin Exp Pathol       Date:  2015-02-01

2.  Determination of polyphenols and in vitro antimicrobial and antioxidant activity of Calluna vulgaris (L.) Hull.

Authors:  Erzsébet Varga; Erika Becsek; Sámuel Gergely Bartha; Szilvia Stranczinger; Fanni Mihalovits; Nóra Papp
Journal:  Biol Futur       Date:  2021-01-10

3.  Metabolism and pharmacokinetics of the anti-tumour agent 2,3,5-trimethyl-6-(3-pyridylmethyl)1,4-benzoquinone (CV-6504).

Authors:  H J Hussey; M J Tisdale
Journal:  Br J Cancer       Date:  1996-11       Impact factor: 7.640

Review 4.  Antimicrobial activity of oleanolic and ursolic acids: an update.

Authors:  Jéssica A Jesus; João Henrique G Lago; Márcia D Laurenti; Eduardo S Yamamoto; Luiz Felipe D Passero
Journal:  Evid Based Complement Alternat Med       Date:  2015-02-22       Impact factor: 2.629

Review 5.  Calluna vulgaris as a Valuable Source of Bioactive Compounds: Exploring Its Phytochemical Profile, Biological Activities and Apitherapeutic Potential.

Authors:  Alexandra-Antonia Cucu; Gabriela-Maria Baci; Alexandru-Bogdan Cucu; Ştefan Dezsi; Cristian Lujerdean; Iuliana Cristina Hegeduş; Otilia Bobiş; Adela Ramona Moise; Daniel Severus Dezmirean
Journal:  Plants (Basel)       Date:  2022-07-30

6.  Effects of Ursolic Acid and its Analogues on Soybean 15-Lipoxygenase Activity and the Proliferation Rate of A human Gastric Tumour Cell Line.

Authors:  D Es-Saady; A Najid; A Simon; Y Denizot; A J Chulia; C Delage
Journal:  Mediators Inflamm       Date:  1994       Impact factor: 4.711

7.  Vernonia polysphaera Baker: Anti-inflammatory activity in vivo and inhibitory effect in LPS-stimulated RAW 264.7 cells.

Authors:  Iara Dos Santos da Silva Oliveira; Aracélio Viana Colares; Flávia de Oliveira Cardoso; Carla Junqueira Moragas Tellis; Maria do Socorro Dos Santos Chagas; Maria Dutra Behrens; Kátia da Silva Calabrese; Fernando Almeida-Souza; Ana Lúcia Abreu-Silva
Journal:  PLoS One       Date:  2019-12-12       Impact factor: 3.240
  7 in total

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