Literature DB >> 1567902

Metabolic conversion of the biologically active phospholipid, lysophosphatidic acid, in fibroblasts.

R L van der Bend1, J de Widt, E J van Corven, W H Moolenaar, W J van Blitterswijk.   

Abstract

Lysophosphatidic acid (3-sn-lysophosphatidic acid; LPA) can activate cells similar to hormones and growth factors. We have considered the question whether metabolic conversion of LPA taken up by the cell could be of any importance in this activation. Addition of [14C-glycerol]LPA to quiescent Rat-1 fibroblasts resulted in rapid formation of [14C]monoacylglycerol (MG), closely followed by accumulation of [14C]triacylglycerol. Only very little [14C]diacylglycerol and [14C]phosphatidic acid was formed (approx. 100-fold less than MG). MG, when added exogenously to cells, lacks detectable biological activity. The results suggest that LPA itself, rather than one of its metabolites is the biologically active principle.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1567902     DOI： 10.1016/0005-2760(92)90163-p

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  10 in total

1.  The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin.

Authors:  R L van der Bend; J de Widt; E J van Corven; W H Moolenaar; W J van Blitterswijk
Journal:  Biochem J       Date:  1992-07-01       Impact factor: 3.857

2.  Kinetic and biochemical correlation between sustained p44ERK1 (44 kDa extracellular signal-regulated kinase 1) activation and lysophosphatidic acid-stimulated DNA synthesis in Rat-1 cells.

Authors:  S J Cook; F McCormick
Journal:  Biochem J       Date:  1996-11-15       Impact factor: 3.857

Review 3.  Autotaxin: structure-function and signaling.

Authors:  Anastassis Perrakis; Wouter H Moolenaar
Journal:  J Lipid Res       Date:  2014-02-18       Impact factor: 5.922

4.  The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.

Authors:  Wenlin Deng; E Shuyu; Ryoko Tsukahara; William J Valentine; Gangadhar Durgam; Veeresa Gududuru; Louisa Balazs; Venkatraman Manickam; Marcello Arsura; Lester VanMiddlesworth; Leonard R Johnson; Abby L Parrill; Duane D Miller; Gabor Tigyi
Journal:  Gastroenterology       Date:  2007-03-24       Impact factor: 22.682

5.  Lysophosphatidic acid is a chemoattractant for Dictyostelium discoideum amoebae.

Authors:  K Jalink; W H Moolenaar; B Van Duijn
Journal:  Proc Natl Acad Sci U S A       Date:  1993-03-01       Impact factor: 11.205

6.  Lysophosphatidic acid and bFGF control different modes in proliferating myoblasts.

Authors:  S Yoshida; A Fujisawa-Sehara; T Taki; K Arai; Y Nabeshima
Journal:  J Cell Biol       Date:  1996-01       Impact factor: 10.539

7.  Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

Authors:  E J van Corven; P L Hordijk; R H Medema; J L Bos; W H Moolenaar
Journal:  Proc Natl Acad Sci U S A       Date:  1993-02-15       Impact factor: 11.205

8.  Mechanism of rapid elimination of lysophosphatidic acid and related lipids from the circulation of mice.

Authors:  Abdel K Salous; Manikandan Panchatcharam; Manjula Sunkara; Paul Mueller; Anping Dong; Yuhuan Wang; Gregory A Graf; Susan S Smyth; Andrew J Morris
Journal:  J Lipid Res       Date:  2013-08-15       Impact factor: 5.922

9.  Peroxisome Proliferator-Activated Receptor γ Regulates the Expression of Lipid Phosphate Phosphohydrolase 1 in Human Vascular Endothelial Cells.

Authors:  Yazi Huang; Beilei Zhao; Yahan Liu; Nanping Wang
Journal:  PPAR Res       Date:  2014-05-12       Impact factor: 4.964

10.  Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

Authors:  R L van der Bend; J Brunner; K Jalink; E J van Corven; W H Moolenaar; W J van Blitterswijk
Journal:  EMBO J       Date:  1992-07       Impact factor: 11.598
  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.