| Literature DB >> 15678378 |
Li-Ming Yang Kuo1, Kuei-Yuh Chen, Shy-Yuan Hwang, Jin-Liang Chen, Yen-Yin Liu, Chia-Ching Liaw, Po-Ho Ye, Cheng-Jen Chou, Chien-Chang Shen, Yao-Haur Kuo.
Abstract
Recently, we found that the MeOH extract of Penicillium oxalicum showed inhibitory activity towards DNA topoisomerase I. Subsequently, ergosterol peroxide, ergosterol, palmitoleic acid, and linoleic acid were isolated from the cultured mycelia of P. oxalicum. The structural determinations were based on physical and spectral analyses. Biological evaluation revealed that ergosterol peroxide inhibited the relaxation of supercoiled DNA (pBR322) induced by DNA topoisomerase I, and also showed marginal, selective cytotoxic activity against human colon tumor cells [COLO-205 (ED50=8.56 microg/mL].Entities:
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Year: 2005 PMID： 15678378 DOI： 10.1055/s-2005-837755
Source DB: PubMed Journal: Planta Med ISSN： 0032-0943 Impact factor: 3.352