M Rajadurai1, P S M Prince. 1. Department of Biochemistry, Annamalai University, Annamalai Nagar 608 002, Tamil Nadu, India.
Abstract
INTRODUCTION: We demonstrate the effect of Aegle marmelos leaf extract (AMLEt) and alpha-tocopherol on plasma lipids, lipid peroxides and marker enzymes in rats with isoproterenol (ISO)-induced myocardial infarction. METHODS: Rats were pre-treated orally for 35 days with different doses of an aqueous AMLEt (50 mg/ kg, 100 mg/kg and 200 mg/kg) prior to ISO-induced myocardial infarction. The effects on creatine kinase, lactate dehydrogenase, plasma thiobarbituric acid reactive substances, lipid hydroperoxides, serum lipids and lipoproteins were studied. RESULTS: Pre-treatment with AMLEt at doses of 100 mg/kg and 200 mg/kg bodyweight for 35 days showed a significant effect on the activities of marker enzymes, lipid peroxides, lipids, lipoproteins and antioxidant enzymes in ISO-treated rats. The effect of AMLEt 200 mg/kg was found to be equal to the effect of alpha-tocopherol 60 mg/kg. CONCLUSION: Aegle marmelos leaves possess antihyperlipidaemic effect in rats with ISO-induced myocardial infarction.
INTRODUCTION: We demonstrate the effect of Aegle marmelos leaf extract (AMLEt) and alpha-tocopherol on plasma lipids, lipid peroxides and marker enzymes in rats with isoproterenol (ISO)-induced myocardial infarction. METHODS:Rats were pre-treated orally for 35 days with different doses of an aqueous AMLEt (50 mg/ kg, 100 mg/kg and 200 mg/kg) prior to ISO-induced myocardial infarction. The effects on creatine kinase, lactate dehydrogenase, plasma thiobarbituric acid reactive substances, lipid hydroperoxides, serum lipids and lipoproteins were studied. RESULTS: Pre-treatment with AMLEt at doses of 100 mg/kg and 200 mg/kg bodyweight for 35 days showed a significant effect on the activities of marker enzymes, lipid peroxides, lipids, lipoproteins and antioxidant enzymes in ISO-treated rats. The effect of AMLEt 200 mg/kg was found to be equal to the effect of alpha-tocopherol 60 mg/kg. CONCLUSION:Aegle marmelos leaves possess antihyperlipidaemic effect in rats with ISO-induced myocardial infarction.
Authors: Kaksha J Patel; Ashwin K Panchasara; Manish J Barvaliya; Bhargav M Purohit; Seema N Baxi; Vishal K Vadgama; C B Tripathi Journal: Res Pharm Sci Date: 2015 Sep-Oct