Literature DB >> 15677865

Diminished production of proinflammatory cytokines in patients with Alzheimer's disease.

E Richartz1, A Batra, P Simon, H Wormstall, M Bartels, G Buchkremer, K Schott.   

Abstract

Cerebral inflammation as well as systemic immunological alterations have been reported in Alzheimer's disease (AD). We examined the production of the proinflammatory cytokines interleukin-6, interleukin-12, interferon-gamma, and tumor necrosis factor-alpha in whole blood cell cultures of AD patients and age-matched controls. The production of all measured cytokines after mitogen stimulation is significantly decreased in the AD group compared to controls. The results reflect an attenuated secretory activity of monocytes/macrophages, but also of T-helper cells. The data sustain the assumption that a systemic, possibly age-related alteration of immune mechanisms may play a pathogenetic role in the development of AD. Copyright 2005 S. Karger AG, Basel.

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Year:  2005        PMID： 15677865     DOI： 10.1159/000083497

Source DB:  PubMed          Journal:  Dement Geriatr Cogn Disord        ISSN： 1420-8008            Impact factor:   2.959


  12 in total

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