BACKGROUND/AIMS: In patients with gliomatosis cerebri (GC), glial fibrillary acidic protein (GFAP) positive cells invade the entire brain, particularly the white matter. Because the nosological definition and histogenesis of GC remain controversial, the morphology and immunohistochemical staining patterns of neoplastic GC cells were compared with those of other gliomas. METHODS: An immunohistochemical analysis of neoplastic cells from four patients with GC and 20 with astrocytic tumours using antibodies against Ki-67, GFAP, and L1, the last of which is a neural cell adhesion molecule putatively related to glioma invasion. RESULTS: GC tumour cells can be divided into two types, those mainly composed of strongly GFAP and L1 positive gemistocytic cells, the other composed of small, GFAP and L1 negative spindle shaped cells. The two types did not differ with respect to Ki-67 positivity. Cells from patients with other gliomas were positive for GFAP but concurrent L1 expression was negative or weakly positive. CONCLUSION: The strong expression of L1 in patients with GC and its poor expression in the 20 patients with other types of glioma, including those with GFAP positive gemistocytic astrocytomas, suggest that L1 expression may play a role in the histogenesis of GC.
BACKGROUND/AIMS: In patients with gliomatosis cerebri (GC), glial fibrillary acidic protein (GFAP) positive cells invade the entire brain, particularly the white matter. Because the nosological definition and histogenesis of GC remain controversial, the morphology and immunohistochemical staining patterns of neoplastic GC cells were compared with those of other gliomas. METHODS: An immunohistochemical analysis of neoplastic cells from four patients with GC and 20 with astrocytic tumours using antibodies against Ki-67, GFAP, and L1, the last of which is a neural cell adhesion molecule putatively related to glioma invasion. RESULTS: GC tumour cells can be divided into two types, those mainly composed of strongly GFAP and L1 positive gemistocytic cells, the other composed of small, GFAP and L1 negative spindle shaped cells. The two types did not differ with respect to Ki-67 positivity. Cells from patients with other gliomas were positive for GFAP but concurrent L1 expression was negative or weakly positive. CONCLUSION: The strong expression of L1 in patients with GC and its poor expression in the 20 patients with other types of glioma, including those with GFAP positive gemistocytic astrocytomas, suggest that L1 expression may play a role in the histogenesis of GC.
Authors: M Noble; M Albrechtsen; C Møller; J Lyles; E Bock; C Goridis; M Watanabe; U Rutishauser Journal: Nature Date: 1985 Aug 22-28 Impact factor: 49.962
Authors: Steve Silletti; Mayra Yebra; Brandon Perez; Vincenzo Cirulli; Martin McMahon; Anthony M P Montgomery Journal: J Biol Chem Date: 2004-05-05 Impact factor: 5.157
Authors: Shideng Bao; Qiulian Wu; Zhizhong Li; Sith Sathornsumetee; Hui Wang; Roger E McLendon; Anita B Hjelmeland; Jeremy N Rich Journal: Cancer Res Date: 2008-08-01 Impact factor: 12.701
Authors: John M Heddleston; Masahiro Hitomi; Monica Venere; William A Flavahan; Kenneth Yang; Youngmi Kim; Sana Minhas; Jeremy N Rich; Anita B Hjelmeland Journal: Curr Pharm Des Date: 2011 Impact factor: 3.116
Authors: Lin Cheng; Qiulian Wu; Zhi Huang; Olga A Guryanova; Qian Huang; Weinian Shou; Jeremy N Rich; Shideng Bao Journal: EMBO J Date: 2011-02-04 Impact factor: 11.598
Authors: Muhua Yang; Shalini Adla; Murali K Temburni; Vivek P Patel; Errin L Lagow; Owen A Brady; Jing Tian; Magdy I Boulos; Deni S Galileo Journal: Cancer Cell Int Date: 2009-10-29 Impact factor: 5.722