BACKGROUND: The aim of this study is to determine carnitine levels in hypoxic-ischemiac neonates. METHODS: Total and free carnitine levels were measured in 20 normal term neonates and 20 term neonates who were diagnosed as hypoxia-ischemia. RESULTS: Both total carnitine levels (43.7 +/- 10.0 microg/dl vice 27.8 +/- 11.8 microg/dl, p<0.0001) and free carnitine levels (28.0 +/- 8.8 vice 13.2 +/- 6.8 microg/dl, p<0.0001) were lower in the hypoxic-ischemic group). Additionally acyl/total carnitine ratio was higher in the asphyxic group (0.33 +/- 0.20 vice 0.56 +/- 0.24, p<0.0001). CONCLUSIONS: The findings of this study show that neonates with hypoxia-ischemia suffer carnitine deficiency.
BACKGROUND: The aim of this study is to determine carnitine levels in hypoxic-ischemiac neonates. METHODS: Total and free carnitine levels were measured in 20 normal term neonates and 20 term neonates who were diagnosed as hypoxia-ischemia. RESULTS: Both total carnitine levels (43.7 +/- 10.0 microg/dl vice 27.8 +/- 11.8 microg/dl, p<0.0001) and free carnitine levels (28.0 +/- 8.8 vice 13.2 +/- 6.8 microg/dl, p<0.0001) were lower in the hypoxic-ischemic group). Additionally acyl/total carnitine ratio was higher in the asphyxic group (0.33 +/- 0.20 vice 0.56 +/- 0.24, p<0.0001). CONCLUSIONS: The findings of this study show that neonates with hypoxia-ischemia suffer carnitine deficiency.
Authors: Brian H Walsh; David I Broadhurst; Rupasri Mandal; David S Wishart; Geraldine B Boylan; Louise C Kenny; Deirdre M Murray Journal: PLoS One Date: 2012-12-05 Impact factor: 3.240
Authors: Thomas F Rau; Qing Lu; Shruti Sharma; Xutong Sun; Gregory Leary; Matthew L Beckman; Yali Hou; Mark S Wainwright; Michael Kavanaugh; David J Poulsen; Stephen M Black Journal: PLoS One Date: 2012-09-11 Impact factor: 3.240
Authors: Marta Reyes-Corral; Noelia Sola-Idígora; Rocío de la Puerta; Joan Montaner; Patricia Ybot-González Journal: Int J Mol Sci Date: 2021-03-03 Impact factor: 5.923