AIMS: To measure hepatic concentrations of the fluorine-containing antimicrobial, sitafloxacin, using in vivo(19)F magnetic resonance spectroscopy (MRS). METHODS: Data were acquired from eight healthy subjects at 2, 5, 8 and 24 h following doses of 500 mg day(-1) for 5 days using a (1)H/(19)F surface coil in a 1.5T clinical MR system. Tissue water was used as a reference. RESULTS: Estimated liver concentrations at 2 h were 15.0 +/- 4.0 microg ml(-1) (mean +/- 95% CI), compared with 3.54 +/- 0.58 microg ml(-1) in plasma (n = 6), and fell below threshold concentrations (2 microg ml(-1)) by 24 h. CONCLUSIONS: (19)F MRS is able to detect and quantify sitafloxacin in the liver. There was no evidence for the hepatic retention of the drug.
AIMS: To measure hepatic concentrations of the fluorine-containing antimicrobial, sitafloxacin, using in vivo(19)F magnetic resonance spectroscopy (MRS). METHODS: Data were acquired from eight healthy subjects at 2, 5, 8 and 24 h following doses of 500 mg day(-1) for 5 days using a (1)H/(19)F surface coil in a 1.5T clinical MR system. Tissue water was used as a reference. RESULTS: Estimated liver concentrations at 2 h were 15.0 +/- 4.0 microg ml(-1) (mean +/- 95% CI), compared with 3.54 +/- 0.58 microg ml(-1) in plasma (n = 6), and fell below threshold concentrations (2 microg ml(-1)) by 24 h. CONCLUSIONS: (19)F MRS is able to detect and quantify sitafloxacin in the liver. There was no evidence for the hepatic retention of the drug.
Authors: P Jynge; T Skjetne; I Gribbestad; C H Kleinbloesem; H F Hoogkamer; O Antonsen; J Krane; O E Bakøy; K M Furuheim; O G Nilsen Journal: Clin Pharmacol Ther Date: 1990-11 Impact factor: 6.875
Authors: M P Findlay; M O Leach; D Cunningham; D J Collins; G S Payne; J Glaholm; J L Mansi; V R McCready Journal: Ann Oncol Date: 1993-08 Impact factor: 32.976
Authors: Brian R Walker; Ruth Andrew; Gregorio Naredo-Gonzalez; Rita Upreti; Maurits A Jansen; Scott Semple; Oliver B Sutcliffe; Ian Marshall Journal: Sci Rep Date: 2022-09-29 Impact factor: 4.996
Authors: C P Lee; G S Payne; A Oregioni; R Ruddle; S Tan; F I Raynaud; D Eaton; M J Campbell; K Cross; G Halbert; M Tracy; J McNamara; B Seddon; M O Leach; P Workman; I Judson Journal: Br J Cancer Date: 2009-12-01 Impact factor: 7.640