Literature DB >> 15675601

Long-term potentiation and cognitive drug discovery.

Sam F Cooke1, Tim V P Bliss.   

Abstract

Long-term potentiation (LTP) is the activity-dependent process by which transmission is persistently enhanced at chemical synapses in the brain. Details of the cellular mechanisms responsible for LTP are becoming clearer, as neuroscientists identify the key molecules in synaptic transmission, and also the signaling cascades, transcription factors and effector molecules that alter transmission at potentiated synapses. In this review we describe the contributions of pharmacology to the field of synaptic plasticity, and also discuss the role of LTP in developing potential nootropic drugs to enhance learning and memory.

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Year:  2005        PMID： 15675601

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  16 in total

Review 1.  Therapeutic potential of positive AMPA receptor modulators in the treatment of neuropsychiatric disorders.

Authors:  Stefano Marenco; Daniel R Weinberger
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

2.  Antiseizure drugs differentially modulate θ-burst induced long-term potentiation in C57BL/6 mice.

Authors:  Peter J West; Gerald W Saunders; Gregory J Remigio; Karen S Wilcox; H Steve White
Journal:  Epilepsia       Date:  2014-01-21       Impact factor: 5.864

3.  Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory.

Authors:  Pamela Maher; Tatsuhiro Akaishi; Kazuho Abe
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-18       Impact factor: 11.205

4.  Negative modulation of GABAA α5 receptors by RO4938581 attenuates discrete sub-chronic and early postnatal phencyclidine (PCP)-induced cognitive deficits in rats.

Authors:  John P Redrobe; Lisbeth Elster; Kristen Frederiksen; Christoffer Bundgaard; Inge E M de Jong; Garrick P Smith; Anne Techau Bruun; Peter H Larsen; Michael Didriksen
Journal:  Psychopharmacology (Berl)       Date:  2011-11-29       Impact factor: 4.530

5.  Fine mapping and expression of candidate genes within the chromosome 10 QTL region of the high and low alcohol-drinking rats.

Authors:  Paula J Bice; Tiebing Liang; Lili Zhang; Tamara J Graves; Lucinda G Carr; Dongbing Lai; Mark W Kimpel; Tatiana Foroud
Journal:  Alcohol       Date:  2010-08-12       Impact factor: 2.405

Review 6.  Organotypic Hippocampal Slices as Models for Stroke and Traumatic Brain Injury.

Authors:  Qian Li; Xiaoning Han; Jian Wang
Journal:  Mol Neurobiol       Date:  2015-07-30       Impact factor: 5.590

7.  Brain slices as models for neurodegenerative disease and screening platforms to identify novel therapeutics.

Authors:  Seongeun Cho; Andrew Wood; Mark R Bowlby
Journal:  Curr Neuropharmacol       Date:  2007-03       Impact factor: 7.363

Review 8.  Serotonergic mechanisms in addiction-related memories.

Authors:  Bríd A Nic Dhonnchadha; Kathryn A Cunningham
Journal:  Behav Brain Res       Date:  2008-07-01       Impact factor: 3.332

9.  A Cell-based beta-Lactamase Reporter Gene Assay for the CREB Signaling Pathway.

Authors:  Menghang Xia; Vicky Guo; Ruili Huang; James Inglese; Marshall Nirenberg; Christopher P Austin
Journal:  Curr Chem Genomics       Date:  2009-01-01

10.  Opposite roles of NMDA receptors in relapsing and primary progressive multiple sclerosis.

Authors:  Silvia Rossi; Valeria Studer; Alessandro Moscatelli; Caterina Motta; Giancarlo Coghe; Giuseppe Fenu; Stacy Caillier; Fabio Buttari; Francesco Mori; Francesca Barbieri; Maura Castelli; Valentina De Chiara; Fabrizia Monteleone; Raffaele Mancino; Giorgio Bernardi; Sergio E Baranzini; Maria G Marrosu; Jorge R Oksenberg; Diego Centonze
Journal:  PLoS One       Date:  2013-06-28       Impact factor: 3.240
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