| Literature DB >> 15675469 |
L Roveda1, U Prati, J Bakeine, F Trotta, P Marotta, P Valsecchi, A Zonta, R Nano, A Facoetti, P Chiari, S Barni, T Pinelli, S Altieri, A Braghieri, P Bruschi, F Fossati, P Pedroni.
Abstract
The purpose of this study was to evaluate boron distribution for a safe and effective BNCT (Boron Neutron Capture Therapy) of liver metastases. Samples both from healthy and tumour liver parenchyma were analysed, after i.v. boron administration, by: alpha particles counting under neutron irradiation; morphological analysis by standard haematoxylin-eosin staining; neutron autoradiography. Our method was unaffected by the cytological heterogeneity inside tumour nodules; it demonstrated selective boron distribution in tumour tissue and predicted estimated mean therapeutic doses in tumour and safety doses in healthy tissue. The time interval for efficient BNCT was 2 to 4 hours after i.v. boron administration.Entities:
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Year: 2004 PMID： 15675469 DOI： 10.1080/1120009x.2004.11782375
Source DB: PubMed Journal: J Chemother ISSN： 1120-009X Impact factor: 1.714