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Literature DB >> 15673787

Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps.

Abstract

Several arylpiperazines capable of reversing multidrug resistance (MDR) in Escherichia coli overexpressing acrAB and acrEF but not in pump-deficient mutant strains were identified. 1-(1-Naphthylmethyl)-piperazine, one of the more active compounds, enhanced susceptibility to fluoroquinolones and other agents and increased the intracellular concentration of levofloxacin and ethidium bromide, suggesting efflux pump inhibition as the mechanism of MDR reversal.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2005 PMID： 15673787 PMCID： PMC547223 DOI： 10.1128/AAC.49.2.849-852.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

9 in total

1. Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin.

Authors: T E Renau; R Léger; E M Flamme; J Sangalang; M W She; R Yen; C L Gannon; D Griffith; S Chamberland; O Lomovskaya; S J Hecker; V J Lee; T Ohta; K Nakayama
Journal: J Med Chem Date: 1999-12-02 Impact factor: 7.446

2. Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.

Authors: M C Sulavik; C Houseweart; C Cramer; N Jiwani; N Murgolo; J Greene; B DiDomenico; K J Shaw; G H Miller; R Hare; G Shimer
Journal: Antimicrob Agents Chemother Date: 2001-04 Impact factor: 5.191

Review 3. Efflux-mediated multiresistance in Gram-negative bacteria.

Authors: K Poole
Journal: Clin Microbiol Infect Date: 2004-01 Impact factor: 8.067

4. Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone.

Authors: A S Jellen-Ritter; W V Kern
Journal: Antimicrob Agents Chemother Date: 2001-05 Impact factor: 5.191

5. 3-Arylpiperidines as potentiators of existing antibacterial agents.

Authors: A Thorarensen; A L Presley-Bodnar; K R Marotti; T P Boyle; C L Heckaman; M J Bohanon; P K Tomich; G E Zurenko; M T Sweeney; B H Yagi
Journal: Bioorg Med Chem Lett Date: 2001-07-23 Impact factor: 2.823

6. Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli.

Authors: W V Kern; M Oethinger; A S Jellen-Ritter; S B Levy
Journal: Antimicrob Agents Chemother Date: 2000-04 Impact factor: 5.191

7. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy.

Authors: O Lomovskaya; M S Warren; A Lee; J Galazzo; R Fronko; M Lee; J Blais; D Cho; S Chamberland; T Renau; R Leger; S Hecker; W Watkins; K Hoshino; H Ishida; V J Lee
Journal: Antimicrob Agents Chemother Date: 2001-01 Impact factor: 5.191

Review 8. Efflux-mediated drug resistance in bacteria.

Authors: Xian-Zhi Li; Hiroshi Nikaido
Journal: Drugs Date: 2004 Impact factor: 9.546

9. Alkylaminoquinolines inhibit the bacterial antibiotic efflux pump in multidrug-resistant clinical isolates.

Authors: Monique Malléa; Abdallah Mahamoud; Jacqueline Chevalier; Sandrine Alibert-Franco; Pierre Brouant; Jacques Barbe; Jean-Marie Pagès
Journal: Biochem J Date: 2003-12-15 Impact factor: 3.857

9 in total

61 in total

Review 1. Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria.

Authors: Laura J V Piddock
Journal: Clin Microbiol Rev Date: 2006-04 Impact factor: 26.132

2. Phenothiazinium antimicrobial photosensitizers are substrates of bacterial multidrug resistance pumps.

Authors: George P Tegos; Michael R Hamblin
Journal: Antimicrob Agents Chemother Date: 2006-01 Impact factor: 5.191

3. Antibacterial properties and mode of action of a short acyl-lysyl oligomer.

Authors: Fadia Zaknoon; Hadar Sarig; Shahar Rotem; Liran Livne; Andrey Ivankin; David Gidalevitz; Amram Mor
Journal: Antimicrob Agents Chemother Date: 2009-06-01 Impact factor: 5.191

4. Inactivation of efflux pumps abolishes bacterial biofilm formation.

Authors: Malin Kvist; Viktoria Hancock; Per Klemm
Journal: Appl Environ Microbiol Date: 2008-10-03 Impact factor: 4.792

Review 5. Efflux-mediated drug resistance in bacteria: an update.

Authors: Xian-Zhi Li; Hiroshi Nikaido
Journal: Drugs Date: 2009-08-20 Impact factor: 9.546

6. Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli.

Authors: Yumiko Takatsuka; Cheng Chen; Hiroshi Nikaido
Journal: Proc Natl Acad Sci U S A Date: 2010-03-08 Impact factor: 11.205

7. Efflux as a glutaraldehyde resistance mechanism in Pseudomonas fluorescens and Pseudomonas aeruginosa biofilms.

Authors: Amit Vikram; Jennifer M Bomberger; Kyle J Bibby
Journal: Antimicrob Agents Chemother Date: 2015-03-30 Impact factor: 5.191

Review 8. The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors: Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal: Clin Microbiol Rev Date: 2015-04 Impact factor: 26.132

Review 9. RND efflux pump mediated antibiotic resistance in Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa: a major issue worldwide.

Authors: Minakshi Puzari; Pankaj Chetia
Journal: World J Microbiol Biotechnol Date: 2017-01-02 Impact factor: 3.312

10. Molecular basis for inhibition of AcrB multidrug efflux pump by novel and powerful pyranopyridine derivatives.

Authors: Hanno Sjuts; Attilio V Vargiu; Steven M Kwasny; Son T Nguyen; Hong-Suk Kim; Xiaoyuan Ding; Alina R Ornik; Paolo Ruggerone; Terry L Bowlin; Hiroshi Nikaido; Klaas M Pos; Timothy J Opperman
Journal: Proc Natl Acad Sci U S A Date: 2016-03-14 Impact factor: 11.205