Literature DB >> 15673785

Effects of cetylpyridinium chloride resistance and treatment on fluconazole activity versus Candida albicans.

Merritt P Edlind1, W Lamar Smith, Thomas D Edlind.   

Abstract

Mouthwash antiseptic cetylpyridinium chloride (CPC) has potent activity against Candida albicans; however, two of five azole-resistant strains showed reduced CPC susceptibility. To further examine the potential for cross-resistance, CPC-resistant mutants were selected in vitro and their fluconazole susceptibility was tested. MICs were unchanged, and trailing growth generally decreased. With CPC-fluconazole combinations, both antagonism and synergism were observed, which can be explained, in part, by CDR1-CDR2 multidrug transporter upregulation.

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Year:  2005        PMID： 15673785      PMCID： PMC547338          DOI： 10.1128/AAC.49.2.843-845.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  19 in total

Review 1.  Biocide abuse and antimicrobial resistance--a cause for concern?

Authors:  A P Fraise
Journal:  J Antimicrob Chemother       Date:  2002-01       Impact factor: 5.790

Review 2.  Mechanisms of antimicrobial action of antiseptics and disinfectants: an increasingly important area of investigation.

Authors:  A D Russell
Journal:  J Antimicrob Chemother       Date:  2002-04       Impact factor: 5.790

Review 3.  Potential impact of increased use of biocides in consumer products on prevalence of antibiotic resistance.

Authors:  Peter Gilbert; Andrew J McBain
Journal:  Clin Microbiol Rev       Date:  2003-04       Impact factor: 26.132

4.  Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.

Authors:  Dominique Sanglard; Françoise Ischer; Michel Monod; Jacques Bille
Journal:  Microbiology (Reading)       Date:  1997-02       Impact factor: 2.777

5.  Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients.

Authors:  S Perea; J L López-Ribot; W R Kirkpatrick; R K McAtee; R A Santillán; M Martínez; D Calabrese; D Sanglard; T F Patterson
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

6.  In vitro effectiveness of mouthrinses against Candida albicans.

Authors:  K Nakamoto; M Tamamoto; T Hamada
Journal:  Int J Prosthodont       Date:  1995 Sep-Oct       Impact factor: 1.681

7.  Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation.

Authors:  W Lamar Smith; Thomas D Edlind
Journal:  Antimicrob Agents Chemother       Date:  2002-11       Impact factor: 5.191

8.  Effect of cetylpyridinium chloride on pathogenic fungi and Nocardia asteroides in sputum.

Authors:  B J Phillips; W Kaplan
Journal:  J Clin Microbiol       Date:  1976-03       Impact factor: 5.948

9.  Resistance mechanisms in clinical isolates of Candida albicans.

Authors:  Theodore C White; Scott Holleman; Francis Dy; Laurence F Mirels; David A Stevens
Journal:  Antimicrob Agents Chemother       Date:  2002-06       Impact factor: 5.191

10.  Effects of chlorhexidine diacetate and cetylpyridinium chloride on whole cells and protoplasts of Saccharomyces cerevisiae.

Authors:  S J Hiom; J R Furr; A D Russell; J R Dickinson
Journal:  Microbios       Date:  1993
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