Literature DB >> 15673784

Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamil.

Rhys Hayward1, Kevin J Saliba, Kiaran Kirk.   

Abstract

As well as having the ability to reverse chloroquine resistance in the human malaria parasite Plasmodium falciparum, verapamil has itself an innate antiplasmodial activity. We show here that mutations in Pgh1, the product of the malaria parasite's pfmdr1 gene, influence the parasite's susceptibility to the toxic effects of verapamil.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15673784      PMCID： PMC547358          DOI： 10.1128/AAC.49.2.840-842.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

1.  Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.

Authors:  M B Reed; K J Saliba; S R Caruana; K Kirk; A F Cowman
Journal:  Nature       Date:  2000-02-24       Impact factor: 49.962

2.  Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance.

Authors:  D A Fidock; T Nomura; A K Talley; R A Cooper; S M Dzekunov; M T Ferdig; L M Ursos; A B Sidhu; B Naudé; K W Deitsch; X Z Su; J C Wootton; P D Roepe; T E Wellems
Journal:  Mol Cell       Date:  2000-10       Impact factor: 17.970

3.  Plasmodium falciparum: modulation by calcium antagonists of resistance to chloroquine, desethylchloroquine, quinine, and quinidine in vitro.

Authors:  D E Kyle; A M Oduola; S K Martin; W K Milhous
Journal:  Trans R Soc Trop Med Hyg       Date:  1990 Jul-Aug       Impact factor: 2.184

4.  Photoaffinity labeling of mefloquine-binding proteins in human serum, uninfected erythrocytes and Plasmodium falciparum-infected erythrocytes.

Authors:  J Desneves; G Thorn; A Berman; D Galatis; N La Greca; J Sinding; M Foley; L W Deady; A F Cowman; L Tilley
Journal:  Mol Biochem Parasitol       Date:  1996-11-25       Impact factor: 1.759

5.  Reversal of chloroquine resistance in Plasmodium falciparum using combinations of chemosensitizers.

Authors:  D A van Schalkwyk; J C Walden; P J Smith
Journal:  Antimicrob Agents Chemother       Date:  2001-11       Impact factor: 5.191

6.  Nucleotide binding properties of a P-glycoprotein homologue from Plasmodium falciparum.

Authors:  S R Karcz; D Galatis; A F Cowman
Journal:  Mol Biochem Parasitol       Date:  1993-04       Impact factor: 1.759

7.  Reversal of chloroquine resistance in Plasmodium falciparum by verapamil.

Authors:  S K Martin; A M Oduola; W K Milhous
Journal:  Science       Date:  1987-02-20       Impact factor: 47.728

Review 8.  ABC transporters and drug resistance in parasitic protozoa.

Authors:  Antonios Klokouzas; Sanjay Shahi; Stephen B Hladky; Margery A Barrand; Hendrik W van Veen
Journal:  Int J Antimicrob Agents       Date:  2003-09       Impact factor: 5.283

9.  Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.

Authors:  Ric N Price; Anne-Catrin Uhlemann; Alan Brockman; Rose McGready; Elizabeth Ashley; Lucy Phaipun; Rina Patel; Kenneth Laing; Sornchai Looareesuwan; Nicholas J White; François Nosten; Sanjeev Krishna
Journal:  Lancet       Date:  2004 Jul 31-Aug 6       Impact factor: 79.321

10.  A P-glycoprotein homologue of Plasmodium falciparum is localized on the digestive vacuole.

Authors:  A F Cowman; S Karcz; D Galatis; J G Culvenor
Journal:  J Cell Biol       Date:  1991-06       Impact factor: 10.539
View more
  7 in total

1.  Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum.

Authors:  Petra Rohrbach; Cecilia P Sanchez; Karen Hayton; Oliver Friedrich; Jigar Patel; Amar Bir Singh Sidhu; Michael T Ferdig; David A Fidock; Michael Lanzer
Journal:  EMBO J       Date:  2006-06-22       Impact factor: 11.598

2.  The neutral lipid composition present in the digestive vacuole of Plasmodium falciparum concentrates heme and mediates β-hematin formation with an unusually low activation energy.

Authors:  Anh N Hoang; Rebecca D Sandlin; Aneesa Omar; Timothy J Egan; David W Wright
Journal:  Biochemistry       Date:  2010-11-08       Impact factor: 3.162

3.  Apparent bias for P. falciparum parasites carrying the wild-type pfcrt allele in the placenta.

Authors:  Nadja Oster; Petra Rohrbach; Cecilia P Sanchez; Katharine T Andrews; Judith Kammer; Boubacar Coulibaly; Gabriele Stieglbauer; Heiko Becher; Michael Lanzer
Journal:  Parasitol Res       Date:  2010-02-11       Impact factor: 2.289

4.  Dynamics of pfcrt alleles CVMNK and CVIET in chloroquine-treated Sudanese patients infected with Plasmodium falciparum.

Authors:  Nahla B Gadalla; Salah Eldin Elzaki; Ebtihal Mukhtar; David C Warhurst; Badria El-Sayed; Colin J Sutherland
Journal:  Malar J       Date:  2010-03-12       Impact factor: 2.979

5.  Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine.

Authors:  Oladosu O Oladipo; Oyibo A Wellington; Colin J Sutherland
Journal:  Diagn Pathol       Date:  2015-04-28       Impact factor: 2.644

6.  Survey of Plasmodium falciparum multidrug resistance-1 and chloroquine resistance transporter alleles in Haiti.

Authors:  Maha A Elbadry; Alexandre Existe; Yves S Victor; Gladys Memnon; Mark Fukuda; John B Dame; Charles A Yowell; Bernard A Okech
Journal:  Malar J       Date:  2013-11-19       Impact factor: 2.979

7.  Assessment of the molecular marker of Plasmodium falciparum chloroquine resistance (Pfcrt) in Senegal after several years of chloroquine withdrawal.

Authors:  Magatte Ndiaye; Babacar Faye; Roger Tine; Jean Louis Ndiaye; Aminata Lo; Annie Abiola; Yemou Dieng; Daouda Ndiaye; Rachel Hallett; Michael Alifrangis; Oumar Gaye
Journal:  Am J Trop Med Hyg       Date:  2012-08-27       Impact factor: 2.345
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.